TRPV1在胃肠道中的病理生理学意义  

The Pathophysiology Role of TRPV1 on Gastrointestinal Disease

作　　者：杨小军[1] 侯晓华[2] 

机构地区：[1]郧阳医学院附属人民医院消化科,湖北十堰442000 [2]华中科技大学同济医学院附属协和医院消化科,武汉430022

出　　处：《医学综述》2008年第23期3551-3552,共2页Medical Recapitulate

摘　　要：TRPV1主要表达在初级传入感觉神经元上,是一种非选择性的阳离子通道。TRPV1可探测和整合炎症和热刺激信号,并转化为动作电位,并传至中枢形成痛觉。在胃肠道及相应背根神经节,TRPV1也有广泛分布。目前,已有诸多证据表明TRPV1可参与胃肠道运动,感觉和吸收等多种重要功能。这些生理学作用在功能性胃肠病的内脏高敏感和胃肠道运动失调的发病中有着重要意义。TRPV1可能为功能性胃肠病提供新的治疗靶点。Transient Receptor Potential Vanilloid 1 （TRPV1） has been identified as a non-selective cationic channel expressed selectively by a sub-population of primary sensory neurons,which also plays an important role in transducing thermal and inflammatory pain. TRPV1 expressed in gastrointestinal tract and dorsal root ganglion （DRG） shows a clear link with gastrointestina motility, visceral sensition and absorption. TRPV1 maybe partly give a explanation to visceral hypersensitivity and dysmotilitv of functional gastrointestinal disease. In the fucture,TRPV1 could be a therapeutic target for functional gastrointestinal disease.

关 键 词：TRPV1 运动 感觉 功能性胃肠病 

分 类 号：R338[医药卫生—人体生理学] R57[医药卫生—基础医学]