人类白细胞抗原与肾小球疾病相关性研究进展  

Progress about Association Between HLA and Glomerular Diseases

作　　者：陆晨[1] 刘伟莉[1] 岳华[1] 

机构地区：[1]新疆维吾尔自治区人民医院肾病科,乌鲁木齐830001

出　　处：《医学综述》2008年第23期3577-3579,共3页Medical Recapitulate

摘　　要：肾小球疾病为一组严重威胁人类健康,最终导致肾衰竭的一类疾病。人类主要组织相容性复合物(HLA系统)位于人第6号染色体短臂,在抗原处理、呈递及T细胞识别中发挥一定的作用。许多研究表明,多种肾小球疾病与HLA相关,现就HLA与慢性肾小球肾炎、小儿特发性肾病综合征、成人肾病综合征及2型糖尿病肾病的相关性作一综述。Glomerular disease is a group of diseases that seriously threaten human health, and ultimately lead to renal failure. Human major histocompatibility complex （ HLA System ）, locates in the short arm of chromosome 6, plays a vital role in the antigen processing, presentation and recognition of T cells. Many studies showed that HLA was related to glomerolar disease. The article reviews HLA and its relationship with chronic glomerular disease, idiopathic nephritic syndrome in ehidren, nephritic syndrome in adult and type 2 diabetic nephropathy.

关 键 词：肾小球疾病 人类白细胞抗原 

分 类 号：R692[医药卫生—泌尿科学]