血液灌流加连续性静脉-静脉血液滤过治疗重度有机磷中毒的应用研究  

Therapeutic efficacy of hemoperfusion combined with continuousvein- vein hemofiltration in treatment of acute severe organophosphorus pesticide poisoning

作　　者：吴志雄[1] 雷航[2] 杨博[1] 叶光福[2] 郑珍香[2] 杨亚东[1] 

机构地区：[1]南方医科大学附属中山市博爱医院,广东中山528403 [2]南方医科大学华瑞医院,广东广州510630

出　　处：《国际医药卫生导报》2008年第24期20-23,共4页International Medicine and Health Guidance News

摘　　要：目的评价血液灌流加连续性静脉-静脉血液滤过治疗重度有机磷中毒的价值。方法53例AOPP患者分为两组，对照组21例行传统治疗，治疗组32例在常规治疗基础上联合运用血液灌流及持续静-静脉血液滤过治疗。观察比较两组的治疗效果。结果治疗组的昏迷持续时间、胆碱酯酶活力恢复时间、住院时间、阿托品应用总量均小于对照组，有显著性差异（P〈0．01）。反跳发生率、中间综合症发生率均小于对照组，有显著性差异（P〈0.05）。结论血液灌流加连续性静脉-静脉血液滤过治疗重度有机磷中毒更为安全而有效。Objective To evaluate the efficacy of hemoperfusion （HP） combined with continuous vein- vein hemofiltration （CVVH） in treating the patients with acute organophosphate pesticide poisoning. Methods 53 patients with acute organophosphate poisoning were divided into two groups, 32 patients were treated with HP , CVVH and traditional treatment（theropy group）, 21 patients accepted traditional treatment （control group）. The treatment effects were compared between the two groups. Results The theropy group, s durati of cholinesterase activity, the cumulative dosages and frequency of hydrochloride and atropine, and unconscious. control groups （P〈0.01）. The incidence of MS the mortality are lower on of the recovery the-penehyclidine than those of the and rebound phenomenonbetween two groups has statistical difference （P〈0.05）.Conclusion hemoperfusion （HP） combined with continuous veinvein hemofiltration （CVVH） in treating the patients with acute organophosphate pesticide poisoning is effective and safety.

关 键 词：血液灌流 持续静-静脉血液滤过 有机磷中毒 

分 类 号：R5[医药卫生—内科学]