FSH受体在大鼠下颌下腺的定位及其与FSH的共存关系  

The Distribution of Follicle Stimulating Hormone Receptor and its Coexistence with Follicle Stimulating Hormone in Rat Submandibular Gland

作　　者：于辉[1] 刘桂云[2] 腾学芹[3] 张秋珍 

机构地区：[1]山东省德州学院医学系内科教研室,山东德州253014 [2]山东省德州学院医学系病理教研室,山东德州253014 [3]山东省德州学院医学系解剖学与组织胚胎学教研室,山东德州253014 [4]不详

出　　处：《解剖科学进展》2008年第4期369-371,共3页Progress of Anatomical Sciences

摘　　要：目的研究大鼠下颌下腺FSH受体的定位及其与FSH的免疫共定位关系,证明下颌下腺是FSH的一个靶器官。方法制备大鼠下颌下腺石蜡连续切片以免疫组化SABC法分别研究FSH和FSHR的免疫定位。结果大鼠下颌下腺浆液性腺泡上皮细胞、颗粒曲管、排泄管及分泌管上皮细胞内有FSHR和FSH免疫反应阳性物质共存,阳性物质分布在胞质内,胞核阴性。结论大鼠下颌下腺存在FSHR,是雌激素的靶器官,而且FSHR和FSH共存于下颌下腺相同的细胞,FSH可能通过FSHR的介导调节下颌下腺的功能。Objective To study the coexistence of follicle-stimulating hormone （FSH） and its receptor （FSHR） in rat submandibular gland in SD rat. Methods Sequential deparaffinized sections of SD rat submandibular glands were immunostained by SABC method. Results FSHR and FSH immunoreactive cells and their colocolization cells were found in glandular epithelial cells of serous acinus, intercalated duct, epithelial cells, granular convoluted epithelial cells and all other duct epithelial cells. The positive substances were distributed in the cytoplasm of all positive cells with negative nuclei. Conclusion The colocolization of FSHR and FSH in rat submandibular gland suggests that submaxillary is a target organ of FSH.

关 键 词：卵泡刺激素 卵泡刺激素受体 免疫组织化学 大鼠 下颌下腺 

分 类 号：R322.4[医药卫生—人体解剖和组织胚胎学]