六氢吡啶催化合成乙酰水杨酸的研究  

Synthesis of Aspirin with Piperidine as Catalyst

作　　者：徐翠莲[1] 陈伟[1] 宛新生[1] 苏惠[1] 党玉丽[1] 

机构地区：[1]河南农业大学理学院,郑州450002

出　　处：《河南科学》2008年第12期1471-1473,共3页Henan Science

基　　金：国家科技攻关项目(2004BA525804)

摘　　要：以水杨酸和乙酸酐为原料,以六氢吡啶为催化剂,合成了乙酰水杨酸,对反应条件进行了优化.结果表明,当水杨酸与乙酸酐物质的量比为1∶3,六氢吡啶为水杨酸质量的17%时,在83℃反应55min,乙酰水杨酸的产率可达88.4%.Acetyl salicylic acid was synthesized from salicylic acid and acetic anhydride catalysed by piperidine. The expected compound could be obtained in 88.4 % yield after heating of the reaction mixtures （the ratio of salicylic acid and acetic anhydride 1：3.0, the mole ratio of piperidine 17 %, 83 ℃ reaction for 30 min）. It showed that acetyl salicylic acid was synthesized in high yield with the catalysis of piperidine.

关 键 词：六氢吡啶 乙酰水杨酸 合成 反应条件 催化 

分 类 号：O625.323[理学—有机化学]