血清ALT升高患者肝炎相关病毒的检测分析  

Pilot study on correlation bwtween elevated serum ALT level and hepatitis-associated viral infection

作　　者：何英[1] 昌利花[1] 张洁云[1] 陆学东[1] 

机构地区：[1]广东医学院附属福田人民医院,广东深圳518033

出　　处：《中国热带医学》2008年第12期2133-2134,2244,共3页China Tropical Medicine

摘　　要：目的探讨血清谷丙转氨酶(ALT)升高与甲、乙、丙、丁、戊、庚型肝炎病毒、柯萨奇病毒(COXV)、巨细胞病毒(CMV)、EB病毒(EBV)、单纯疱疹病毒(HSV)、输血传播病毒(TTV)感染的相关性。方法采用聚合酶链反应与核酸测序技术对240例血清ALT升高患者的血清标本进行病毒核酸检测。结果在血清ALT升高人群中,病毒检出率从高至低依次为HBV(70.83%,170/240)、EBV(12.50%,30/240)、COXV(7.50%,18/240)、TTV(7.50%,18/240)、CMV(4.17%,10/240)、HEV(1.67%,4/240)、HAV(1.67%,4/240)、HCV(0.83%,2/240),HDV、HGV、HSV未有检出。重叠感染率为20.83%,其中二重感染占72.00%,重叠感染者中绝大多数可检出HBV感染。结论HBV感染史是造成血清ALT升高主要原因,但在临床诊治过程中,不应忽视病毒重叠感染因素。Objective To investigate the correlation between elevated serum ALT level and hepatitis-associated viral infection. Methods Serum samples from 240 patients with elevated serum ALT levels were determined by using PCR and DNA sequencing method. Results The positive rate of virus detection among patients with high ALT levels were in the order of： HBV（70.83%, 170/240）, EBV （12.50%, 30/240）, COX （7.50%,18/240）, TTV（7.50%,18/240）, CMV （4.17%, 10/240）, HEV （1.67%,4/240）, HAV （1.67%,4/240）, HCV （0.83%, 2/240）. While HDV, HGV, HSV were not detected. The highest infection rate, mainly with HBV, was 20.83% and ddual infections occupies 72.00%. Conclusion The history of HBV infection is the leading cause resulting in the elevation of serum ALT level and attention be paid to dual infections during clinical manangemnet.

关 键 词：ALT 肝炎相关病毒 聚合酶链反应 

分 类 号：R373.2[医药卫生—病原生物学] R446[医药卫生—基础医学]