辛伐他汀辅助治疗充血性心力衰竭的临床疗效观察  

The clinical survery about the adjunctive therapy of Simvastatin on congestive heart failure for 40 cases

作　　者：李俊民[1] 郑彩霞[1] 吕伟[1] 

机构地区：[1]淮北市中医院内三科,安徽省235000

出　　处：《中国心血管病研究》2008年第12期928-929,共2页Chinese Journal of Cardiovascular Research

摘　　要：目的观察辛伐他汀辅助治疗充血性心力衰竭(CHF)的疗效和不良反应。方法将76例CHF患者随意分为治疗组40例,对照组36例,对照组予常规强心、利尿、硝酸酯类药物及血管紧张素转换酶抑制剂(AcEI),治疗组在与对照组同样治疗上加用辛伐他汀治疗。两组治疗后评价疗效及不良反应。结果临床疗效,治疗组总有效率(90%)明显高于对照组(62%)(P<0.05);左室舒张功能比较治疗组各项指标改善显著高于对照组(P<0.05),两组比较差异均有统计学意义。结论应用辛伐他汀辅助治疗充血性心力衰竭能改善心功能、逆转左室重构,改善心力衰竭患者预后,并且无明显不良反应,是较为理想的治疗药物。Objective To observe the adjunctive therapy of Simvastatin on congestive heart failure and adverse effect. Methods The total 76 CHF patients were divided into the experimented group （40 cases） and the control group （36 cases）. The patients in the control group were treated by the drugs which can strengthen cardiac function,diuresis,the nitrate and ACEI. Compared with the control group,the simvastatin was applied to the patients in the experimented on the basis of the based treatments which were the same in the control groupo The therapeutic effect and the adverse effect were evaluated after treatment. Results According to the clinic effect, the total effect （90%）in the experiment group was much higher than in the control group（62% ）（P〈0.05）. Compared with the control group,the diastolic function of the left ventricle was proved much better in the experiment group,the distinction between the both groups has the statistical significance. Conclusion Simvastatin which was applied adjunctively to treat CHF can improve heart function,reverse the left ventricular reconstruction and the prognosis for the CHF, and without any obviousive adverse effects,so it which was proved was an ideal drug for the CHF.

关 键 词：辛伐他汀 心力衰竭 左室重构 

分 类 号：R541.61[医药卫生—心血管疾病]