高血压心脏病患者血浆超敏C反应蛋白的变化  

Detection of High Sensitivity C-Reactive Protein Level in Patients with Hypertensive Heart Disease

作　　者：庞慧 宫海滨[2] 张居洋[3] 张光彩[3] 黄文利[4] 薛莹[4] 

机构地区：[1]江苏省徐州市心血管病研究所,221009 [2]徐州市心血管病研究所,徐州市中心医院心内科 [3]徐州市中心医院核医学科 [4]徐州市中心医院体检中心

出　　处：《中华全科医学》2008年第12期1220-1221,共2页Chinese Journal of General Practice

基　　金：国家自然科学基金资助项目(30572073);江苏省自然科学基金项目(DK2005428);江苏省卫生厅重大项目(K200402);江苏省医学重点人才(RC2007024)

摘　　要：目的探讨高血压性心脏病患者血浆超敏C反应蛋白水平的变化,为早期防治高血压心脏靶器官损害提供理论依据。方法选择徐州市中心医院门诊或心内科住院的55例原发性高血压患者,分为两组:高血压组30例和高血压心脏病组25例。对照组为同期该院体检中心健康体健者40例。上述所有入选者均自愿参加观察。采用化学发光法测定血浆超敏C反应蛋白含量。结果超敏C反应蛋白:高血压组(1423.44±565.75)ng/ml显著高于对照组(291.35±117.22)ng/ml(P<0.01),高血压心脏病组(4195.90±1968.76)ng/ml显著高于高血压组(P<0.01),与对照组比较,P<0.01。结论该实验结果提示血浆超敏C反应蛋白水平的变化与原发性高血压的病情程度密切相关,此可能对于预测原发性高血压患者不良事件的发生以及病情变化具有重要的临床意义。Objective To investigate the plasma concentrations of high sensitivity C-reactive protein（hs-CRP） in patients with hypertensive heart disease in hopes of providing theoretic evidence for early treatment and prevention of target organ damage caused by hypertensive heart disease. Methods 55 patients with essential hypertension who hospitalized at the Central Hospital of Xuzhou were divided into hypertension group（ n = 30） and hypertensive heart disease group（ n = 25 ）. 40 healthy individuals were selected as control. The plasma concentrations of hs-CRP in all cases were measured by chemiluminescence method. Results The level of hs-CRP in the hypertension group （ 1 423.44 ± 565.75 ） ng/ml was significantly higher than that of the control group （291.35 ± 117.22）ng/ml ;and （4 195.90 ±1 968.76）ng/ml in the hypertensive heart disease group with target organ damage was significantly higher than those of hypertension.group and control group （ all P 〈 0.01 ）. Conclusions The level of high sensitivity C-reactive protein is associated with the course of the patients with essential hypertension, which may contribute to essential hypertension accident as a better predictor of risk.

关 键 词：高血压性心脏病 超敏C反应蛋白 原发性高血压 

分 类 号：R541.3[医药卫生—心血管疾病]