流感嗜血杆菌临床分布与耐药性分析  

Analysis on clinical distribution and antimicrobial resistance of hemophilies influenzae

作　　者：刘英[1] 杨长顺[1] 刘筱玲[1] 周细国[1] 周旭[1] 

机构地区：[1]湖南省怀化市第一人民医院检验科,418000

出　　处：《检验医学与临床》2008年第23期1423-1424,共2页Laboratory Medicine and Clinic

摘　　要：目的了解流感嗜血杆菌的临床分布及其耐药性。方法采用卫星实验对154株流感嗜血杆菌进行鉴定,纸片琼脂扩散(K-B)法进行药敏试验,采用头孢硝噻吩滤纸片法进行β-内酰胺酶检测。结果154株流感嗜血杆菌科室分布以感染科(40株)、神经呼吸内科(32株)、老年中医科(30株)为主;对氨苄西林、环丙沙星、阿奇霉素和复方新诺明耐药性较高,耐药率均大于60.00%,美罗培南和氨曲南的抗菌活性好,耐药率分别为0.00%、8.44%;流感嗜血杆菌产β-内酰胺酶率为20.13%。结论流感嗜血杆菌耐药率高且具有多重耐药性,临床应加强监测并根据药敏结果合理选用抗菌药物进行治疗。Objective To investigate the clinical distribution and antimicrobial resistance of hemophilies influ enzae. Methods Hemophilies influenzae was identified with satellite test. K-B method was applied for the drug susceptibility test,and nitrocefin test was used to detect β-lactamase. Results A total of 154 strains of hemophilies influ- enzae were mainly distributed in infection department （40 strains）,department of neurology and respiratory diseases （32 strains） and department of traditional Chinese medicine （30 strains）. The resistant rates to ampicil!in,ciprofloxa- cin,azithromycin and compound sulfamethoxazole were all above 60.00%, the resistant rates to meropenem and aztreonam were 0.00% and 8.44% respectively. The positive rate of β-lactamase was 20.13 %. Conclusion Hemophilies influenzae has high resistant rate and the drug resistance displays multiple. It suggests that antibacterials should be chosen according to antimicrobial susceptibility test results.

关 键 词：微生物 流感嗜血杆菌 临床分布 耐药性 

分 类 号：R446.5[医药卫生—诊断学] R969.4[医药卫生—临床医学]