TGF-β1诱导的肺泡Ⅱ型上皮细胞间质转化与肺纤维化  

Transforming growth factor-β1-induced epithelial-mesenchymal transition of rat type Ⅱ alveolar epithelium and pulmonary fibrosis

作　　者：徐国萍[1] 许祖德[1] 沈惠芬[1] 杨丽荣[1] 陈海滨[1] 

机构地区：[1]大理学院基础医学院病理教研室,671000

出　　处：《国际呼吸杂志》2008年第21期1341-1344,共4页International Journal of Respiration

基　　金：云南省大理学院博士基金资助项目

摘　　要：肺纤维化（pulmonary fibrosis，PF）是多种间质性肺疾病的共同结果，也是引起慢性呼吸衰竭的重要原因之一。近年研究发现纤维化病灶内部分增生的成肌纤维细胞可能是通过上皮细胞向间质细胞转化而来的。本文就PF发病过程中上皮细胞向间质细胞转化的病理意义、分子机制及防治意义进行综述，为进一步明确PF的病因和发病机制，制定有效治疗方案提供研究手段。Pulmonary fibrosis（PF） is the common result of manifold interstitial pulmonary diseases. Several studies stated that a part of proliferative myofibroblasts in the fibrotic focus are from alveolar epithelial mesenchymal transition. The review focuses the pathological significance,molecular mechanism and the prevention and cure of epithelial-to-mesenchymal transition in the process of PF, thereby to provide the research means for establishing the effective treatment scheme and further identify the pathogeny and pathogenesis of PF.

关 键 词：转化生长因子Β1 上皮细胞间质转化 肺泡上皮 肺纤维化 

分 类 号：R563[医药卫生—呼吸系统]