高密度脂蛋白抗动脉粥样硬化的新认识  

New Insight on the Anti-artherosclerosis Function of High-density Lipoprotein

作　　者：梁东辉[1] 陈允钦[1] 吴鹏[1] 杨俊[1] 

机构地区：[1]南方医科大学珠江医院,广东广州510282

出　　处：《辽宁中医药大学学报》2008年第12期22-24,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：广东省自然科学基金资助项目(06024432)

摘　　要：血清高密度脂蛋白(High density lipoprotein,HDL)具有抗As的作用,HDL水平与冠心病发病率呈明显的负相关,低HDL-C是冠心病的独立的危险因素。HDL通过多种机制发挥其抗动脉粥样硬化作用,其中最重要的是参与胆固醇的逆向转运(reverse cholesterol transport,RCT),阻止巨噬细胞转化为泡沫细胞,防止胆固醇在动脉壁沉积,并将胆固醇从血管壁运送至肝脏被清除,从动态平衡的思路认识HDL的代谢及其功能,认为中医脾的运化和传输功能可能与HDL代谢及RCT密切相关,提出健脾益气中药可能有促进RCT的作用,进一步研究可望为研发调节RCT的中药新药和防治冠心病提供线索。It is known that serum high-density lipoprotein（HDL） functions mainly to antiartherosclerosis. HDL level correlates negatively to the morbidity of coronary heart disease（CHD）. Low HDL level is confirmed to be the independent risk factor of CHD. HDL functions to anti-artherosclerosis by many means, of which reverse cholesterol transport（RCT） is the most important one. HDL can inhibit the transformation of macrophage to foam ceil, prevent the deposition of cholesterol to artery walls, and transport cholesterol from vessel walls in peripheral to liver for further cleaning. This paper will analyze the metabolism and functions of HDL from a viewpoint of dynamic balance, presume that the transportation and transformation function of spleen may relate closely to the metabolism and RCT function mediated by HDL, and propose that invigorating the spleen and benefiting the vital energy may help to promote RCT function. To make a further study on HDL will help to develop novel Traditional Chinese Medicines（TCM） which function to regulate RCT, and to offer some new insights or means to the prevention and treatment of CHD.

关 键 词：高密度脂蛋白 动脉粥样硬化 胆固醇逆向转运 血清脂蛋白动态平衡 脾虚证 

分 类 号：R543.5[医药卫生—心血管疾病]