通乳散癖汤对乳腺增生病模型大鼠的影响  

Effect of Tongru Sanpitang on Hyperplasia of Mammary Glands in Model Rats

作　　者：李朝平[1] 刘迎萍[2] 

机构地区：[1]甘肃中医学院,甘肃兰州730000 [2]甘肃省中医院,甘肃兰州730020

出　　处：《中国中医药信息杂志》2008年第12期34-36,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：甘肃省自然科学基金暨中青年科技基金项目(3ZS041-A25-067)

摘　　要：目的探讨通乳散癖汤治疗乳腺增生病作用机理、环节、最佳用药剂量。方法将动物分为空白组、模型组、乳癖消片组及通乳散癖汤高、中、低剂量组,除空白组外,其余各组用苯甲酸雌二醇及黄体酮联合造模,实验中期给予药物灌胃。检测大鼠雌二醇(E2)、促卵泡素(FSH)、促黄体生成素(LH)、雌激素受体(ER),观察乳腺、子宫、卵巢组织形态学变化,计算子宫、卵巢重量及其脏器系数。结果各组大鼠E2、FSH、ER均有不同程度的降低,乳腺、子宫、卵巢有不同程度的恢复。结论通乳散癖汤可能是通过降低乳腺对E2的敏感性,调节性腺轴,从而调节整体机能,且存在量效关系。Objective To research the mechanisms and the link of therapy and the optimal dosage of Tongru Sanpitang on hyperplasia of mammary glands in model rats. Methods Rats were randomly divided into 6 groups： negative contronl group, model group, Rupixiao Tablets group and Tongru Sanpitang low, middle, high dose group. Model was made with complex method of Progesterone and Estradiol benzoatehad injected into abdominal. In the middle of experiment, rats were given different drug respectively. Estradiol, follicle stimulating hormone, luteinizing hormone, the expression of estrogen receptor, weight of the ovary and uterus and visceral coefficient were determined. Results Follicle stimulating hormone, luteinizing hormone, the expression of estrogen receptor in medicine group decreased. The ovary and uterus in electron microscope, weight of organs and organ coefficient were improved. Conclusion Tongru Sanpitang may adjust reproductive endocrine function by decreasing sensitivity of mammary glands to estradiol and adjust whole function in the treatment of hyperplasia of mammary glands. There are dose-effect relationship.

关 键 词：通乳散癖汤 乳腺增生病 大鼠 

分 类 号：R289.11[医药卫生—方剂学]