SFE-CO_2和超声法提取丹参药渣的对比研究  

Comparative Study of SFE-CO_2 and Ultrasonic in Extracting the Water Decocted Radix Salviae Miltiorrhiza

作　　者：张明[1] 刘汉清[1] 韩晓珂[1] 马俊华 马继永 

机构地区：[1]南京中医药大学,江苏南京210046 [2]山东华信制药有限公司,山东济南274009

出　　处：《中国中医药信息杂志》2008年第12期59-60,62,共3页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的探讨不同提取工艺提取丹参药渣中丹参酮ⅡA成分含量,以便对丹参药渣综合利用。方法采用超临界二氧化碳(SFE-CO2)萃取丹参酮ⅡA,并与超声提取法相比较。结果SFE-CO2萃取的最佳工艺为萃取压力35MPa,夹带剂乙醇用量为100%,萃取温度40℃,萃取时间2h,含量高达3.87mg;而超声提取法只有2.89mg。结论用SFE-CO2萃取丹参药渣中丹参酮ⅡA,其提取率及纯度均高于超声提取法,且丹参药渣可以综合利用。Objective To study the different extraction methods for the content of tanshinone Ⅱ A in water decocted Radix Salviae Miltiorrhiza, in order to develop comprehensive utilization of Salvia miltiorrhiza. Method Tanshinone Ⅱ A was extracted by supercritical carbon dioxide fluid and compared with ultrasonic extraction. Result When the extraction pressure was 35 MPa, extraction temperature was 40 ℃, extraction time was 2 h and entrainer （ethanol） was 100 %, the yields of the tanshinone ⅡA was up to 3.87 mg, while the ultrasonic extraction was 2.89 mg. Conclusion Tanshinone ⅡA extracted by supercritical carbon dioxide fluid was better than ultrasonic extraction and had higher purity. The comprehensive utilization of Salvia miltiorrhiza is available.

关 键 词：水提丹参药渣 超临界二氧化碳 丹参酮Ⅱ A 提取工艺 正交设计 

分 类 号：R283.5[医药卫生—中药学]