血液科医院感染致病菌分布及耐药性分析  

Analysis of the Distribution and Drug resistance of Nosocomial Infection Pathogenic Bacteria in Hematology Wards

作　　者：吴蓓倩[1] 冷海燕[1] 丁天凌[1] 柏岚[2] 阮斐怡[2] 许小平[1] 

机构地区：[1]复旦大学附属华山医院血液科,上海200040 [2]复旦大学附属华山医院检验中心,上海200040

出　　处：《中国医药导刊》2008年第8期1222-1223,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:分析血液科住院病人医院感染致病菌分布及耐药情况。方法:回顾性研究我院发生医院感染的血液病住院病人2003年11月～2007年11月细菌送检阳性的390份标本,药敏试验用Kirby-Bauer法。结果:390株细菌依次分布于呼吸道分泌物、尿液、血液等标本。G^-菌占62.05%,G^+菌37.95%。单纯的头孢类和青霉素类抗生素除头孢他啶外,对G^-菌的敏感性不高,而碳青霉烯类、加β^-内酰胺酶抑制剂的头孢三代类和青霉素类对G^-菌敏感性较高。G^+菌对万古霉素、替考拉宁100%敏感,而对各种头孢类、青霉素类和喹诺酮类抗生素均显示出很高的耐药性;咽拭子及血标本中的金黄色葡萄球菌100%耐甲氧西林,仅万古霉素及替考拉宁100%敏感。结论:我院血液科医院细菌感染仍以G^-菌为主,G^+菌的比例处于上升趋势。呼吸道感染最常见。金黄色葡萄球菌100%耐甲氧西林。Objective：To investigate clinical distribution and drug sensitivity of infection pathogens in our hematology wards.Methods：To analysis the 390 bacterial strains of pathogens isolated from all detected samples in last four years.Drug sensitivity tests of bacteria were performed by Kirby-Bauer method.Results：The main infection site was respiratary site,the next were urinary tract and bloodstream infections.The composition ratio of Gram - negtive bacteria,Gram-positive bacteria was 62.05%,37.95%.The drug-resistance to the commone antibiootics was very severe.All of staphylococcies were resistant to meticillin,and sensitive to vancomycin.Conclusion：This study indicates that Gram-negative bacteria remain the predominant pathogens is our Hematology wards.The main infection site was respiratary site.All of staphylococcies were resistant to meticillin.

关 键 词：血液病 院内感染 致病菌 药物敏感性 

分 类 号：R446.5[医药卫生—诊断学]