苏木乙酸乙酯提取物在同种异位心脏移植大鼠供体心脏中分布的研究  

The Distribution Research of Sappan Acetic Ether Extract in the Heart of Homogenetic Heterotopic Heart Transplantation Rats

作　　者：李涛[1] 魏江波 徐春杰 周亚滨[4] 

机构地区：[1]北京中医药大学,北京100029 [2]大庆中医院,大庆163111 [3]大庆油田庆虹桥医院,大庆163711 [4]黑龙江中医药大学,哈尔滨150040

出　　处：《国际中医中药杂志》2008年第6期403-404,共2页International Journal of Traditional Chinese Medicine

摘　　要：目的 通过研究苏木乙酸乙酯提取物在同种异位心脏移植大鼠供体及原位心脏中的分布情况，探讨苏木免疫活性部位在大鼠移植心脏分布的选择性。方法采用改良Ono术式复制大鼠同种异位心脏移植模型，将手术成功鼠随机分为模型组和实验组（苏木组）。通过反相HPLC法，检测苏木提取物在移植大鼠供体及原位心脏中的分布。结果苏木提取物在移植心脏色谱图出现一种苏木原型成分，其余为代谢产物：在原位心脏色谱图未出现苏木原型成分。结论苏木原型成分存在于大鼠移植心脏中，而不存在于原位心脏中。表明苏木成分在移植心脏中的分布可能具有选择性。Objective Through studying the distribution of the Sappan acetic ether extract in transplanted heart of rats, to discuss selectivity of sappan in donor＇s hearts. Methods Improved Ono model was used to replicate the heart transplantation model of rats. Successfully operated rats were separated into 2 groups： a model group and a sappan group. Distributions of sappan in transplanted heart were observed by HPLC-FPC. Results One kind of original substance of sappan was detected in transplanted heart sample, but not in un-transplanted hearts. Conclusion The substance of sappan may have selectivity in transplanted heart.

关 键 词：苏木乙酸乙酯提取物 免疫抑制 大鼠心脏移植 HPLC 

分 类 号：R654.2[医药卫生—外科学] R978.7[医药卫生—临床医学]