冬连胶囊对糖尿病大鼠蛋白非酶糖基化的影响  

Effect Donglian Capsule on Nonenzymatic Protein Glycation in Diabetes Melitus Rat

作　　者：孙其伟[1] 高普[1] 刘剑刚[1] 

机构地区：[1]中国中医科学院西苑医院,北京100091

出　　处：《国际中医中药杂志》2008年第6期407-408,共2页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金（项目编号：30873257）

摘　　要：目的观察冬连胶囊对蛋白非酶糖基化的干预作用。方法采用小剂量链脲佐菌素（STZ）腹腔注射，配合高脂饮食制备糖尿病大鼠模型，给药12周后观察冬连胶囊对大鼠血糖、糖化血清蛋白（GSP）、醛糖还原酶（AR）的影响。结果较空白对照组，模型组血糖明显升高；冬连胶囊高剂量组和西药对照组大鼠血糖有下降趋势，较模型对照组有显著性差异（P〈0．05）；冬连胶囊高、低剂量组和西药对照组均能降低大鼠GSP含量、抑制AR活性，较模型对照组有显著性差异（P〈0．01）。结论冬连胶囊对蛋白非酶糖基化反应有抑制作用。Objective To observe the effect of Donglian capsule on nonenzymatic protein glycation. Methods An animal model of DM was established by injecting a little dosage of STZ in high fat-fed rats. When the models were established successfully, corresponding medicines were supplied for 12 weeks and then the blood glucose, glycosylation serum protein （GSP） and aldose reductase （AR） in rats serum were measured. Results Comparing with the model group, the levels of blood glucose, GSP and AR in Metformin Hydrochloride tablets group and Chinese medicine group were decreased markedly （P〈0.05）. Conclusion Donglian capsule can restrain nonenzymatic protein glycation and so thus prevent and treat DM.

关 键 词：冬连胶囊 糖化血清蛋白 醛糖还原酶 蛋白非酶糖基化 

分 类 号：R28[医药卫生—中药学]