阿奇霉素颗粒剂溶出度测定方法的研究  

Study on dissolution of azithromycin granules

作　　者：金建平[1] 

机构地区：[1]安徽省芜湖市药品检验所,安徽芜湖241000

出　　处：《安徽医药》2008年第12期1158-1159,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的研究测定阿奇霉素颗粒剂溶出度的方法。方法采用浆法,用磷酸盐缓冲液（pH 6.0）为溶出介质,转速100 r.min^-1,紫外-可见分光光度法482 nm波长处测定吸光度。结果30 min的溶出量不少于标示量的75%,测定的线性范围为15.0-120.0 g.L^-1,r=0.9992（n=5）,平均回收率为99.7%（RSD=0.63%）,方法的重现性和精密度良好。结论方法快速、简便,结果准确,能满足质量控制的要求。Aim To study the dissolution of azithromycin granules. Methods pH os-phato buffer solution（pH6.0）was used as the dissolution medium,the rotative velocity was 100 r · min^-1 , and ultraviolet spectrophotometry was used with a max absorption peak at the wave length of 482 nm. Results The standard curve was linear over the range of 15.0 - 120.0 g · L^-1, r = 0.9992 （ n = 5）. The average recovery was 99.7% （RSD = 0.63% ）. Conclusion The method was simple and accurate. It can be used for the assay of azithromycin granules.

关 键 词：阿奇霉素 颗粒剂 溶出度 测定方法 

分 类 号：R927[医药卫生—药学]