Ligudentatin A的全合成  

Total Synthesis of Ligudentatin A

作　　者：张晨曦[1] 毕福强[1] 李裕林[1] 

机构地区：[1]兰州大学有机化学研究所功能有机分子化学国家重点实验室,兰州730000

出　　处：《高等学校化学学报》2008年第11期2191-2193,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20272021)资助

摘　　要：以(+)-紫苏醇2为起始原料,经氧化、Witting、Diels-Alder和烯酮的芳构化等反应,最终以17.7%的总收率完成了去甲基倍半萜Ligudentatin A(1)的全合成,其中Diels-Alder和烯酮的芳构化反应为关键步骤.Ligudentatin A （1）, a new phenolic norsesquiterpenes, was first synthesized starting from （ ＋ ）- perillalalcohol 2 through six steps, successively, with an overall yield of 17. 7%. The key steps were the Diels-Alder reaction and aromatization of enone to phenol. The advantages of this ap yields and the ease with which the reaction can be carried out with readily available materials and reagents under mild conditions.

关 键 词：Ligudentatin A 全合成 DIELS-ALDER反应 芳构化反应 

分 类 号：O621.3[理学—有机化学]