银杏叶提取物对老年冠心病患者冠脉血流和内皮功能的影响  

Influence of Ginkgo biloba extract on coronary flow and endothelial function in aged patients with coronary heart disease

作　　者：李淑琴[1] 武宇洲[2] 祖秀光[2] 都军[2] 王凤飞[2] 

机构地区：[1]河北医科大学病理生理教研室,河北050017 [2]河北医科大学第二医院

出　　处：《北京中医药大学学报》2008年第10期712-714,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：河北省科技攻关资助项目(No.99276129D);河北省科技支撑计划资助项目(No.07276450)

摘　　要：目的研究银杏叶提取物(GBE)对老年冠心病(CAD)患者冠脉血流和内皮功能的影响。方法50例老年CAD患者随机分为GBE注射液治疗组和对照组,两组均于用药前、后采用血管超声检测冠状动脉左前降支(LAD)血流和血流介导的肱动脉内皮依赖性血管舒张(FMD)的变化。结果GBE注射液显著增加LAD舒张期峰值流速(DPV)、收缩期峰值流速(SPV)和舒张期时间速度积分(DTVI)(P<0.01),同时FMD显著升高(P<0.01);而对照组冠脉血流和FMD无明显变化(P>0.05)。Pearson线性相关分析显示,LAD血流流速(DPV,SPV和DTVI)的增加与FMD的改善呈正相关(P<0.01)。结论GBE注射液可增加老年CAD患者LAD血流,其机理可能与FMD的改善有关。Objective To study the effect of Ginkgo biloba extract （GBE） on coronary flow and endothelial function in aged patients with coronary heart disease （CHD）. Method The patients with CHD （n = 50） were randomly divided into the treatment group treated with GBE injection and control group. Before and after the intravenous injection, the blood flow of left anterior descending coronary artery （LAD） and changes of flow-mediated endothelium-dependent vasodilation （FMD） of brachial artery in two groups were detected by using vascular ultrasound. Result In the GBE group diastolic peak velocity （DPV）, systolic peak velocity （SPV） and diastolic time velocity integral （DTVI） of LAD were improved significantly by GBE （P 〈0.01 ） and FMD of brachial artery was increased （P 〈0.01 ）. In the control group LAD flow and FMD of brachial artery did not change （P 〉 0.05 ）. The Pearson analysis showed that the improvement of DPV, SPV and DTVI of LAD was correlated to the promotion of FMD of brachial artery （P 〈 0.01 ）. Conclusion GBE injection can improve LAD flow in aged patients with CHD, which may be related to the promotion of FMD of brachial artery.

关 键 词：冠心病 银杏叶提取物 内皮功能 冠脉血流显像 

分 类 号：R285.6[医药卫生—中药学]