基于证候动态变化的病毒性肺炎疗效评价方法研究  

Syndrome Variation based TCM Therapeutic Effects Evaluation for Virus Pneumonia and Associated Methodology

作　　者：汪受传[1] 赵霞[1] 任现志[1] 杨燕[1] 艾军[1] 李瑞丽[1] 谢雁鸣[2] 白文静[2] 

机构地区：[1]南京中医药大学,南京210029 [2]中国中医科学院,北京100700

出　　处：《世界科学技术-中医药现代化》2008年第5期10-15,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家“十五”科技攻关计划项目(2004BA716B03):“中医药治疗病毒性肺炎疗效评价方法研究”，负责人：汪受传。

摘　　要：目的:建立能够同时反映治疗方案干预后的阶段疗效和终点疗效的病毒性肺炎证候疗效评价方法。方法:以多中心、区组随机、平行对照临床试验结果作生存分析,寻找证候疗效产生的"拐点",探讨基于起效时间的证候评分方法和疗效分级评价方法。以新方法与基于主症动态变化评价方法对本次临床研究作疗效评价对照。结果:提出了基于证候动态变化的疗效评价方法。且该方法与基于主症动态变化评价方法对本次临床研究疗效评价结果存在正相关关系。结论:基于证候动态变化的病毒性肺炎疗效评价方法,更能全面、准确、客观地反映不同方案治疗病毒性肺炎的证候疗效,能彰显中医药辨证治疗优势,是一种值得推广应用的中医药治疗病毒性肺炎疗效评价方法。Here, efforts are made to establish a method to evaluate the TCM syndromes that mirror the terminal and phase effects of virus pneumonia treatment. In the study, a survival-analysis was made based on the results of multi-center, block randomization, parallel control clinic test, and syndrome variation trends. Clinical test results were evaluated using both the new syndrome score and effect degree based method and the traditional terminal syndrome based method. A new therapeutic effect evaluation method was created based on syndrome variations. The result of the clinical tests using the new evaluation method shows a positive correlation with the traditional method, indicating that the new evaluation method enjoys the strength of traditional Chinese medicine, and deserve wider applications.

关 键 词：病毒性肺炎 证候动态变化 疗效评价方法 

分 类 号：R654.2[医药卫生—外科学] R725.631[医药卫生—临床医学]