造影剂使用对中性粒细胞明胶酶相关脂质运载蛋白水平的影响  

The variation of urinary neutiophil gelatinase-associated lipocalin in the patients after contrast examination

作　　者：万辛[1] 吴文芳[1] 曹长春[1] 张立元[1] 

机构地区：[1]南京医科大学附属南京第一医院肾内科,江苏南京210006

出　　处：《南京医科大学学报（自然科学版）》2008年第11期1378-1380,共3页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金资助(30670984);南京市医学科技发展项目资助(ZKM06039)

摘　　要：目的:观察接受CT增强扫捕和静脉肾盂造影检查的患者使用造影剂前后尿液中中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平的变化,探讨造影剂对肾脏的损伤作用。方法:选择34例接受CT增强扫描和静脉肾盂造影检查的患者,分别留取造影剂使用前后不同时间点的血液和尿液标本,测定血液标本中的肌酐(Scr)水平和尿液标本中的NGAL水平。结果:34例患者无1例发生造影剂肾病;注射造影剂后2、8、24、48和72 h的Scr水平与造影前相比,差异无统计学意义(P>0.05);注射造影剂后2、8 h尿NGAL水平明显升高,与造影前相比,差异有统计学意义(P<0.05)。结论:造影剂使用后Scr水平升高不明显的患者,尿NGAL水平在早期已有明显升高,提示已出现早期的肾脏损害。Objective：To investigate the kidney injury in the patients after contrast examination. Methods：34 patients underwent CT enhancement scanning or intravenous pyelography were enrolled in this study. The concentration of Scr and urine NGAL at different time points were measured. Results：None of contrast-induced nephropathy （CIN） occurred in 34 enrolled patients. After the contrast examination,Scr did not significantly change at any time point but urine NGAL significantly elevated at 2 h and 8 h. Conclusion： Early kidney injury occurred in the patients after the contrast examination without the change of Ser level.

关 键 词：造影剂 明胶酶类 肾脏损伤 

分 类 号：R692.9[医药卫生—泌尿科学]