奥美拉唑治疗急性重型脑出血并发应激性溃疡及胃酸变化  

Effect of Omeprazole on Stress Ulcer Followed Acute Severe Hypertensive Cerebral Hemorrhage and Gastric Acid Change

作　　者：孙飞[1] 赵建平[1] 王博[1] 

机构地区：[1]徐州市中心医院脑外科,江苏徐州221009

出　　处：《黑龙江医药》2008年第6期26-27,共2页Heilongjiang Medicine journal

摘　　要：目的:探讨奥美拉唑和雷尼替丁对重型脑出血并发上消化道出血患者胃酸分泌的影响。方法:60例患者随机分组:奥美拉唑组、雷尼替丁组;所有病例均于应用抑酸药前、用药后3,12,24,72h监测胃液pH及消化道出血情况。结果:重型脑出血并发上消化道出血时胃液pH值低,奥美拉唑组较雷尼替丁组能显著升高胃内pH P<0.05。结论:重型脑出血并发上消化道出血胃酸呈高分泌状态。奥美拉唑对应激性溃疡的胃酸抑制和止血效果均优于雷尼替丁。Objective： To evaluate the efficacy of Omeprazole and Ranitidine on gastric acid secretion on stress ulcer followed acute severe hypertensive cerebral hemorrhage.Methods： Sixty patients were divided randomly into two groups： Oneprazole group and ranitidine group.Gastric pH monitoring were conducted before antiacid and 3hours, 12hours, 24hours,72hours after antiasid and define homeostatic time.Results： In stress ulcer followed acute severe hypertensive cerebral hemorrhage patients the intragastric pH was significantly decreased.Omeprazole could block the decrease of the intragastric pH comoaring with Ranitidine group （p〈0.05）.Conclusion： These was hypersecretion of the gastricacid in stress ulcer followed acute severe hypertensive cerebral hemorrhage patients.Omeprazole could better block the decrease of the intragastric pH and homeostasis than that of Ranitidine.

关 键 词：奥美拉唑 上消化道出血 重型脑出血 胃酸 

分 类 号：R975.6[医药卫生—药品]