抗菌硅橡胶导尿管材料的合成及其性能  

Synthesis and characterization of antibacterial silicon rubber catheters

作　　者：路新卫[1,2] 韦莉萍[1] 朱全红[1] 杨建华[1] 

机构地区：[1]南方医科大学中医药学院内科教研室,广东省广州市510315 [2]南方医科大学药学院化学系,广东省广州市510515

出　　处：《中国组织工程研究与临床康复》2008年第41期8091-8094,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：广东省卫生厅医学科研基金资助项目(A2004411)~~

摘　　要：背景:前期实验已成功制备纳米抑菌复合材料——丁胺卡那-蒙脱土复合材料。目的:在前期实验基础上制备丁胺卡那-蒙脱土/硅橡胶片抗菌复合导尿管材料,测试其相关热学、力学性能以及抗菌性能,并与全硅橡胶材料相比较。设计、时间及地点:对比分析,体外实验,于2006-05/2007-04在香雪制药股份有限公司实验室完成。材料:自制丁胺卡那/蒙脱土复合材料;甲基乙烯基硅橡胶为江西宏达化工新材料股份有限公司生产。方法:取生胶和抗菌负载蒙脱土用双辊开炼机混炼,然后加入硫化剂,用平板压力机压板制样,硫化温度170℃,硫化时间10min,制得4个不同胶料配方的胶,分别为每100份硅橡胶中添加0,5,7.5,10份丁胺卡那/蒙脱土复合材料。主要观察指标:差示扫描量热仪表征其热学性能,偏光显微镜观察微观结构;通过体外释放及抑菌实验检测抗菌活性和缓释效果。结果:丁胺卡那-蒙脱土复合材料/硅橡胶结晶温度不同程度向低温迁移,其中每100份硅橡胶中添加7.5份丁胺卡那/蒙脱土复合材料变化较大,达到-38.50℃,材料的力学性能有不同程度的提高,有效抗菌时间可以达到21d。结论:丁胺卡那-蒙脱土复合材料/硅橡胶导尿管材料具有良好的力学性能、抗菌性能及缓释效果。BACKGROUND： Previously, amikacin/organo-montmorillonite （OMMT） has been successfully prepared as an antibacterial nano-composite material. OBJECTIVE： To prepare silicon rubber/amikacin-OMMT composite as an antimicrobial composite catheter, to test its properties of thermology, mechanics and antibiosis, and to compare it with pure silicon rubber. DESIGN, TIME AND SETTING： Contrast analysis experiments in vitro were carried out in the laboratory of Xiangxue Pharmaceutical Stock Co.,Ltd from May 2006 to April 2007. MATERIALS： Methyl vinyl silicone rubber was provided by Jiangxi Hongda New Chemical Materials Co., Ltd. Amikacin-OMMT composite was self-made. METHODS： Raw silicon rubber and OMMT composites were mixed by a double-roller open refiner, and then sulfurized with the added vulcanizer at 170 ℃for 10 minutes. Four kinds of film samples with different adhesive masses were prepared by a flat plate piercer, every 100 samples of silicon rubbers were seperatively supplemented with 0, 5, 7.5, 10 samples of amikacin-OMMT composite. MAIN OUTCOME MEASURES： Differential scanning calorimeter was used to detect thermotical property; polarizing microscope was utilized for the microstructure observation; Antimicrobial activity and slow-release effect were determined by in vitro bacteriostasis and release, respectively. RESULTS： The crystallization temperature of silicone rubber/amikacin-OMMT composite decreased at different degrees, with the lowest temperature -38.50℃ at 7.5 phr. The mechanical property of the synthetical material was improved, and the antibiosis activity lasted for 21 days at the most. CONCLUSION： The silicone rubber/amikacin-OMMT composite shows that its mechanical property, antimicrobial activity and slow-release effect are satisfying.

关 键 词：抗菌 硅橡胶 导尿管 丁胺卡那/蒙脱土复合材料 

分 类 号：R318[医药卫生—生物医学工程]