多囊卵巢综合征性激素变化与认知功能的临床观察  

A clinical study of the cognitive function of patients with polycystic ovary syndrome

作　　者：刘锦霞[1] 段立晖[2] 吴静静[1] 于淼[1] 吴元赭[1] 吴效科[3] 

机构地区：[1]南京军区南京总医院妇产科,江苏南京210002 [2]南京军区南京总医院干部神经科,江苏南京210002 [3]黑龙江中医药大学附属第一医院妇产科,黑龙江哈尔滨150040

出　　处：《医学研究生学报》2008年第11期1161-1163,共3页Journal of Medical Postgraduates

基　　金：国家“十一五”科技支撑计划基金资助项目(批准号:2007BAI20B015)

摘　　要：目的:研究多囊卵巢综合征(PCOS)患者认知功能的变化,并探讨其与雄激素的关系。方法:选择PCOS患者(PCOS组)及健康自愿者(对照组)各25例,放射免疫测定其血浆睾酮(T)、硫酸脱氢表雄酮(DHEAS)、性激素结合蛋白(SHBG)、雌二醇(E2)、卵泡刺激素(FSH)和黄体生成素(LH)。认知功能测定包括词语学习及延迟回忆、言语流畅性、符号数字替代模式、连线测验A、数字广度和积木测验。结果:PCOS组患者血中T、LH、SHBG与对照组比较差异有显著性统计学意义(P<0.01);其动物言语流畅性测验和连线测验A较对照组显著性下降(P<0.05)。结论:PCOS患者存在认知功能损害,这可能与其血中雄激素增高有关。Objective ： To observe the changes of the cognitive function of patients with polycystic ovary syndrome （PCOS） and explore their relationship with serum testosterone. Methods： The levels of serum testosterone （T）, dehydroepiandrosterone sulfate （DHEAS）, sex hormone binding globulin （SHBG）, Estradiol （ E2 ）, follicle-stimulating hormone （FSH） and luteotrophic hormone （LH） were measured by radioimmunity assay in 25 patients with PCOS and 25 normal women. Their cognitive functions were assessed by delayed word recall test, word learning test, symbol digit substitution test, animals category fluency test, block design, trail making test （Part A） and digit span test. And the results of the tests were compared between the PCOS and the normal group. Results： The levels of serum T, LH and SHBG in the PCOS patients differed significantly from the normal individuals （P 〈 0.01）. The cognitive performance of the patients showed a significant decrease in the tests of digit span and animals category fluency, as compared with the normal women （P 〈 0.01 ）. Conclusion： The cognitive function was impaired in the patients with PCOS, which may be related with the increased level of serum testosterone.

关 键 词：多囊卵巢综合征 认知功能 激素变化 临床观察 

分 类 号：R711.75[医药卫生—妇产科学]