^(18)氟去氧葡萄糖PET/CT显像对胃癌的应用价值  

Value of ^(18)Fluorodexyglucose PET/CT for gastric carcinoma

作　　者：吴江[1] 朱虹[1] 王中秋[2] 童金龙[3] 常林凤[1] 胡裕效[1] 王新刚[1] 黄红丽[1] 

机构地区：[1]南京大学医学院临床学院(南京军区南京总医院)核医学科,江苏南京210002 [2]南京大学医学院临床学院(南京军区南京总医院)医学影像科,江苏南京210002 [3]南京大学医学院临床学院(南京军区南京总医院)肿瘤科,江苏南京210002

出　　处：《医学研究生学报》2008年第11期1181-1186,共6页Journal of Medical Postgraduates

基　　金：南京军区医学科学技术研究"十一五"计划课题资助项目(批准号:06MA120)

摘　　要：目的:探讨18氟去氧葡萄糖(18FDG)PET/CT对胃癌的应用价值。方法:对临床怀疑胃癌的32例患者(男25例,女7例,年龄31~82岁)行18FDG PET/CT显像,显像前饮水600 ml扩张胃腔,PET图像对目测阳性病灶勾画感兴趣区(ROI),并测量最大标准摄取值(SUVmax),CT图像测量胃壁增厚的最大厚度,所有患者均通过手术或胃镜取得病理结果。结果:经18FDG PET/CT检查的32例患者中,发现胃癌24例。18FDG PET/CT对胃癌诊断的阳性预测值、阴性预测值和准确性分别为92.3%、100%和93.8%。胃癌患者的SUVmax与胃壁厚度呈正相关,有无淋巴结转移与SUVmax及胃壁厚度的差异均无显著性统计学意义;根据PET/CT检查结果对24例胃癌患者进行临床分期:Ⅰ期9例,Ⅰ~Ⅱ期1例,Ⅱ期3例,Ⅲ期1例,Ⅳ期10例。结论:18FDG PET/CT显像对胃癌的诊断、生物学行为评价及临床治疗策略的选择有重要价值。Objective： To investigate the value of positron emission tomography/computerized tomography （PET/CT） with fluorine-18-1abeled fluorodeoxyglucose （18 FDG） for gastric carcinoma. Meth- ods ： Thirty-two patients （25 males, 7 females, aged 31 - 82 years） suspected of gastric carcinoma underwent whole-body PET/CT after taking in 600 ml of water to distend the gastral cavity. The maximal standard uptake value （ SUVmax） of the region of interest （ROI） in PET and the maximum width of the gastric wall in CT were analyzed. Pathological specimens were obtained from all the patients during surgery or gastroscopy. Results：^18FDG PET/CT found gastric carcinoma in 24 of the patients. The rates of positive and negative prediction and the accuracy of PET/CT in the diagnosis of the disease were 92.3%, 100% and 93.8%. SUVmax was positively correlated with the maximum width of the gastric wall, but they exhibited no statistically significant differences between the patients with involved lymph nodes and those without. Based on the PET/CT findings, the 24 gastric carcinoma patients were clinically classified as follows： 9 in stage Ⅰ , 1 in stage Ⅰ - Ⅱ , 3 in stage Ⅱ , 1 in stage Ⅲ and 10 in stage Ⅳ. Conclusion： ^18FDG PET/CT is highly valuable for gastric carcinoma in its diagnosis, the evaluation of its biological behavior and determination of its treatment strategies.

关 键 词：胃癌 ^18氟去氧葡萄糖 正电子发射型计算机断层扫描 计算机断层扫描 

分 类 号：R814.42[医药卫生—影像医学与核医学]