瘦素与儿童肥胖研究进展  

Progress in the study of leptin and childhood obesity

作　　者：孟扬[1] 汪俊军[1] 

机构地区：[1]南京军区南京总医院解放军临床检验医学研究所,江苏南京210002

出　　处：《医学研究生学报》2008年第11期1211-1213,1218,共4页Journal of Medical Postgraduates

基　　金：国家自然科学基金资助项目(批准号:30872411);江苏省自然科学基金青年科技创新人才资助项目(批准号:BK2006529)

摘　　要：瘦素(leptin)是一种主要由脂肪组织产生的蛋白激素,直接作用于下丘脑,参与能量平衡的调节,在机体肥胖的产生过程中起着重要作用。体内存在多种瘦素蛋白受体亚型,其中可溶性的瘦素受体(sOb-R)可调节瘦素水平,具有很高的检测价值。相关研究显示,瘦素很有可能成为判断儿童肥胖风险的标记物,瘦素水平还可被用来评估肥胖儿童对运动干预的应答性。Leptin, a proteohormone primarily made by adipocytes, directly interacts with the hypothalamus for energy balance regulation. It plays an important role in the morbility of obesity. The soluble leptin receptor （sOb-R） is one of the leptin receptor isoforms. The examination of the sOb-R concentration is valuable because of its function in the regulation of leptin concentration. Leptin shows a great potential as a childhood obesity biomarker, and its concentration could be used in assessing the responsiveness of obese children to intervention programs.

关 键 词：瘦素 儿童肥胖 瘦素受体 蛋白激素 

分 类 号：R589.2[医药卫生—内分泌]