急性冠状动脉综合征患者血清金属蛋白酶变化的临床意义  

Clinical Significance of Serum Matrix Metalloproteinases Level Changes in Acute Coronary Syndrome

作　　者：俞晓丽[1] 闻平[1] 郭月芳[2] 陈蕾[2] 

机构地区：[1]镇江市第一人民医院检验科,江苏镇江212002 [2]江苏大学附属医院,江苏镇江212001

出　　处：《现代检验医学杂志》2008年第6期108-109,共2页Journal of Modern Laboratory Medicine

摘　　要：目的探讨急性冠状动脉综合征患者金属蛋白酶(MMP-2,MMP-9)、氧化低密度脂蛋白(oxLDL)、屏氧酶1(paranoxonase-1,PON-1)变化的临床意义。方法以ELISA法和生化方法检测87例急性冠状动脉综合征(ACS)患者、37例稳定型心绞痛(SAP)患者和23例健康人血清MMP-2,MMP-9,oxLDL和PON-1。结果急性心肌梗死(AMI)组和不稳定型心绞痛(UAP)组患者的MMP-2,MMP-9,oxLDL和PON-1均显著高于对照组(P<0.01),尤其以AMI组最高;AMI组、UAP组的检测结果与SAP组患者的MMP-2,MMP-9,oxLDL和PON-1也存在显著性差异(P<0.01);SAP组患者的MMP-2,MMP-9,oxLDL和PON-1的含量稍高于健康对照组(P<0.05)。结论MMP-2,MMP-9,oxLDL和PON-1在ACS患者血浆中均显著增高,可作为ACS患者诊断的敏感性指标之一。Objective To explore the clinical significance of serum the matrix metalloproteinases （MMP-2,MMP-9）,oxidative low density lipoprotein （oxLDL）,paranoxonase-1 （PON-1） level changes in acute coronary syndrome patients. Methods MMP-2,MMP-9,oxLDL and PON-1 in sera were detected by enzyme-linked immunosorbent assay （ELISA） and colorimetric assay from 87 ACS patients, 37 stable angina patients （SAP） and 23 normal healthy control. Results MMP-2,MMP-9 and oxLDL were more higher in ACS group compared with normal healthy control group and SAP group while PON-1 activity was lower. These changes were gently in SAP patients. Conclusion Serum MMP-2,MMP-9,oxLDL and PON-1 levels were changed siglnficantly in acute coronary syndrome group and can be used as markers of acute coronary syndrome.

关 键 词：金属蛋白酶 氧化低密度脂蛋白 屏氧酶1 急性冠状动脉综合征 

分 类 号：R543.3[医药卫生—心血管疾病] R446.112[医药卫生—内科学]