燃煤污染型砷中毒患者头发中微量元素与砷中毒关系探讨  

The Relationship between Hair Trace Elements and Arsenic Poisoning in Arsenism Patient Caused by Coal-burning

作　　者：张爱华[1] 陈浪[1] 张然[1] 李军[1] 赵转地[1] 邹志林[1] 黄晓欣[2] 张碧霞[2] 

机构地区：[1]贵阳医学院卫生毒理学教研室,贵州贵阳550004 [2]中国人民解放军第44医院,贵州贵阳550009

出　　处：《贵阳医学院学报》2008年第6期593-596,共4页Journal of Guiyang Medical College

基　　金：国家自然科学基金资助项目(30460123);贵州省优秀人才省长专项基金(黔省专合字380号);贵州省重大专项基金(黔科合重大专项字6016号)

摘　　要：目的:检测燃煤污染型砷中毒患者头发中微量元素含量,探讨其与砷中毒的关系,为砷的毒作用机制分析及辅助性诊断和干预提供参考依据。方法:采用原子吸收光谱法测定107例砷中毒患者和30例对照人群头发中的铜(Cu)、锰(Mn)、锌(Zn)、铁(Fe)、钙(Ca)、镁(Mg);原子荧光光谱法测定砷(As)、硒(Se)含量。结果:砷中毒患者发中的Se、Zn、Ca、Mg明显低于对照组;Cu、Fe、Mn、As明显高于对照组,差异均有统计学意义;砷中毒不同病情组Se、Zn和Cu、Fe、Mn、As等含量有随病情加重而降低或升高的趋势。结论:砷可影响人体内微量元素的平衡,微量元素的失衡可能是砷毒作用的重要机制之一。Objective ： To explore the relationship between arsenism and trace elements in hair of ar-senism patients caused by coal-burning, so as to provide bases for theoretical study, diagnosis, and in- tervention of arsenism. Methods： For 107 arsenism patients and 30 healthy people （as control）, the concentrations of Cu, Mn, Zn, Fe, Ca, and Mg in hair were measured with Flame Atomic Absorption Spectrometry, and the concentrations of As, and Se were tested with Flame Atomic Fluorescence Spec-trometry. The data were analyzed statistically. Results： The concentrations of Se, Zn, Ca and Mg were lower and the concentrations of Cu, Fe, Mn and As were higher significantly in the hair of patients than those of control group; There was a trend that concentrations of Se, Zn, Cu, Fe and Mn in hair of arsenism patients decreased or increased along with the aggravating of the disease. Conclusions： Arsenic can effect the balance of trace elements in humans body and the unbalance of trace elements may be one of the important mechanisms of arsenism. To monitor and to supplement some trace elements with known effects such as Zn and Se will be helpful for diagnosis and intervention of arse-nism.

关 键 词：痕量元素 钙 镁 砷中毒 毛发 

分 类 号：R595.9[医药卫生—内科学]