基于壳聚糖-纳米金粒子的生物传感器的构造与应用研究进展  

Research Progress in Construction and Application of Biosensors Based on Chitosan Gold Nanoparticles

作　　者：杨文[1] 罗明灯[1] 郝文涛[1] 吴叶兵[1] 何建波[1] 

机构地区：[1]合肥工业大学化工学院可控化学与材料化工安徽省重点实验室,合肥230009

出　　处：《材料导报》2008年第12期68-70,84,共4页Materials Reports

基　　金：安徽省青年教师资助计划(2007jq1005);合肥工业大学学生创新基金项目(XS08038)

摘　　要：对近年来基于壳聚糖-纳米金粒子的生物传感器的构造与应用研究进行了回顾与总结。在结合纳米金粒子独特的物理化学特性和壳聚糖良好的生物相容性,壳聚糖与酶及纳米金粒子等良好的结合能力特性基础上,通过不断改进电极结构,使用层-层复合技术以及添加碳纳米管或纳米金丝的方法,能构造出具有很高灵敏度和检测极限的纳米复合材料生物传感器。通过改变结合酶的品种,可以获得具有不同检测环境和检测物质适应性的生物传感器。对生物传感器的应用也进行了相应的总结。The recent research progress in the construction and application of biosensors based on chitosan-gold nanoparticles is reviewed. By combining the unique physical and chemical properties of gold nanoparticles and the excellent biocompatibility/good conjugation ability to enzyme and gold nanoparticles of chitson, nanocomposite biosensors with high sensitivity and low detection limitation are prepared through modifying the structure of electrode, using the layer-by-layer assembly and addition of carbon nanotubes or gold filament. Biosensors suitable for different detection environment and materials are also constructed by changing the enzymes attached on the biosensors, The application of biosensors is also reviewed.

关 键 词：生物传感器 壳聚糖 纳米金粒子 构造 应用 

分 类 号：O657[理学—分析化学]