Identification of major histocompatibility complex class I alleles in Chinese rhesus macaques  

作　　者：Dongyun Ouyang Lihui Xu Zhengxi Dai Huanjing Shi Gaohong Zhang Yongtang Zheng Xianhui He 

机构地区：[1]Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China [2]Institute of Bioengineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China [3]Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Diseases Mechanisms, Kunrning Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China [4]Graduate School of the Chinese Academy of Sciences, Beijing 100039, China

出　　处：《Acta Biochimica et Biophysica Sinica》2008年第11期919-927,共9页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grants from the National Natural Science Foundation of China （No. 30572199, No. 30230350 and No. 30371651） to Prof. XH He; the Talented Man Initiation Fund of Jinan University （No. 51208004 and No. 51208017） and Natural Science Fund of Guangdong Province （No. 8451063201000340） to Dr. DY Ouyang; the Scientific and Technological Projects of Yunnan （2004NG12 and 2006PT08）, the Major State Basic Research Development Program of China （2006CB504208）, the Knowledge Innovation Program of CAS （KSCX1-YW-R-15） to Dr. YT Zheng, and ＂Western Light＂ Projects to Dr. GH Zhang; as well as by the Biochemistry and Molecular Biology Key Discipline of Guangdong Province; Acknowledgements We thank Dr. Natasja de Groot, Dr. Nel Otting and IMGT Nonhuman Primate Nomenclature Committee for naming the Mamu-A and Mamu-B sequences.

摘　　要：Major histocompatibility complex （MHC） class I information is vital for understanding variance of immune responses in HIV vaccination and biomedical models. In this study, 9 Mamu-A and 13 Mamu-B alleles were identified from the cDNA products of 10 Chinese-origin rhesus macaques. Except for two alleles that had been reported by others, eight were novel and twelve extended the partial sequences that are available in GenBank. The additional information of MHC class I antigens might be beneficial to the availability of Chinese macaques in human disease studies. Furthermore, the polymorphism of leading peptides and the natural killer receptor recognition motifs in al domain both implies that Mamu.A and Mamu-B molecules might play key roles in innate immune responses of natural killer cells.Major histocompatibility complex （MHC） class I information is vital for understanding variance of immune responses in HIV vaccination and biomedical models. In this study, 9 Mamu-A and 13 Mamu-B alleles were identified from the cDNA products of 10 Chinese-origin rhesus macaques. Except for two alleles that had been reported by others, eight were novel and twelve extended the partial sequences that are available in GenBank. The additional information of MHC class I antigens might be beneficial to the availability of Chinese macaques in human disease studies. Furthermore, the polymorphism of leading peptides and the natural killer receptor recognition motifs in al domain both implies that Mamu.A and Mamu-B molecules might play key roles in innate immune responses of natural killer cells.

关 键 词：Mamu-A Mamu-B MHC class I rhesus macaque 

分 类 号：Q95[生物学—动物学]