腺性膀胱炎动物模型的尿流动力学检查  

Urodynamics of cystitis glandularis animal model in SD rats

作　　者：易憬[1] 熊飞[2] 苏良平[1] 陈登[1] 杨向利[2] 杨兵[1] 张盛龙[1] 张宝珍[1] 刘长[1] 章慧平[2] 

机构地区：[1]武钢大冶铁矿医院泌尿外科,湖北黄石435000 [2]华中科技大学同济医学院计划生育研究所

出　　处：《临床泌尿外科杂志》2008年第11期865-867,共3页Journal of Clinical Urology

摘　　要：目的:探索SD大鼠腺性膀胱炎尿流动力学检查方法。方法:将50只SD大鼠分成3组:模型组采用DH5α大肠杆菌溶液,隔两日灌注雌性SD大鼠膀胱诱导产生腺性膀胱炎动物模型;盐水对照组采用生理盐水每隔两日膀胱灌注,共持续45天;空白组不采取任何干预措施,同条件饲养。45天后行尿流动力学检查及病理检测。结果:尿动力学检查提示模型组大鼠储尿期膀胱逼尿肌不稳定发生率与对照组、空白组相比差异有统计学意义(P<0.001)。结论:确立了腺性膀胱炎的动物模型尿流动力学检查方法。Objective：To study an accessible urodynamics approach for cystitis glandularis in SD rats. Methods： 50 female SD rats were randomized into three groups. E. coli solution was infused into the bladders of test rats within 2 days intermittently to induce cystitis glandularis. And normal saline into control group with same method. No measurement was admitted to the blank group. The animals were breed in same condition. Changes of urodynamics and pathology were evaluated in 45 days later. Results： According to urodynamic test, the results estimated that there existed significant difference between test group and the other two groups （P〈0. 001）. Conclusions：From this study, the urodynamics approach was established for animal model of cystitis glandularis.

关 键 词：腺性膀胱炎 动物模型 尿流动力学 

分 类 号：R694[医药卫生—泌尿科学]