50例Rh阴性血型孕妇的妊娠结局分析  

Analysis of Pregnancy Outcomes in 50 Rh-negative Pregnant Women

作　　者：刘舒鑫[1] 姚若进[1] 朱欣[1] 

机构地区：[1]中南大学湘雅医院,湖南长沙410008

出　　处：《实用妇产科杂志》2008年第11期685-688,共4页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:探讨Rh阴性血型孕妇孕期处理、妊娠结局及其影响因素。方法:对住院分娩的50例Rh阴性孕妇进行回顾性分析,观察其临床特点、孕期处理及妊娠结局,并随机抽取同期分娩的50例Rh阳性孕妇作为对照组。结果:Rh阴性孕妇早产、新生儿高胆红素血症发生率均高于对照组,差异有高度统计学意义及统计学意义(P<0.01,<0.05);随孕产次增加围生儿溶血病发生率增高,差异有统计学意义(P<0.05);ABO血型相合者较不相合者Rh血型抗体产生率要高,差异有统计学意义(P<0.05);血浆置换、人血丙种免疫球蛋白及宫内输血可明显改善胎儿及新生儿溶血情况。结论:对Rh阴性妇女加强孕期监护,必要时抽脐血检查并积极给予血浆置换、宫内输血等综合治疗,可延长胎龄,提高围生儿的存活率和生存质量。Objective i To investigate the management, pregnancy outcome and influential factors of Rh-negative pregnant women. Methods：50 pregnant women of Rh negative blood type were retrospectively observed. The clinical feature, management and pregnancy outcome were recorded.50 cases over the same period of Rh-positive pregnant women were enrolled as a control group. All cases in the two groups were enrolled yiversity iewedhad no other pregnancy complications. Results： The incidence of premature birth and neonatal hyperbilirubinemia in test group was higher than that of control group （ P〈 0.01）. The incidence of newborn hemolytic disease increased with the accrescence of pregnancy times and antibody titer, （ P〈 0.05）.The positive rate of Rh antibody was higher in the mothers with ABE） compatibility compared with those with ABO incompatibility （ P 〈 0.05）. Plasmapheresis, immuneglobulin and intrauterine transfusion could improve the situation of hemolytic disease of fetus and newborn. Conclusions; Guardianship should be enhanced for Rh-negative women during pregnancy. When necessary, comprehensive treatment such as cordocentesis,plasmapheresis and intrauterine transfusion should be implied to extend gestational age and boost perinatal infant survival and quality of life.

关 键 词：RH阴性血型 宫内输血 血浆置换 新生儿溶血病 

分 类 号：R714[医药卫生—妇产科学]