唾液酸Lewis-X在慢性鼻-鼻窦炎鼻黏膜组织中的表达  

Expression of SleX in nasal epithelium with chronic rhinosinusitis

作　　者：朱学伟[1] 朱冬冬[1] 孙克巍[1] 王宇声[2] 董震[1] 

机构地区：[1]吉林大学中日联谊医院耳鼻咽喉头颈外科,长春130033 [2]吉林大学第一医院耳鼻咽喉头颈外科

出　　处：《临床耳鼻咽喉头颈外科杂志》2008年第20期917-919,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金面上项目(No:30772409);卫生部重点学科资助项目;吉林省科技发展项目白求恩专项基金资助项目(No:200705275)

摘　　要：目的:探讨唾液酸Lewis-X(SleX)在慢性鼻-鼻窦炎鼻黏膜组织中的表达。方法:利用SleX单克隆抗体,通过免疫组织化学技术对9例慢性鼻-鼻窦炎患者鼻黏膜组织及7例正常对照鼻黏膜组织进行染色,分析SleX在鼻黏膜组织中的表达。结果:SleX在鼻黏膜上皮细胞及中性粒细胞均有表达。SleX在慢性鼻-鼻窦炎鼻黏膜上皮细胞中的表达阳性率为88.9%,在正常鼻黏膜上皮细胞中的表达阳性率为14.3%,差异有统计学意义(P<0.05)。结论:SleX在慢性鼻-鼻窦炎黏膜组织高表达,可能参与慢性鼻-鼻窦炎的发生。Objective：To explore the expression of SleX in nasal epithelium in patients with chronic rhinosinusitis. Method：Nine nasal epitheliums from patients with chronic rhinosinusitis and 7 normal controls were stained with SleX antibody by immunohistochemistry, and its expression were analyzed. Result：Both nasal epithelial cells and neutrophils expressed SleX. Nearly 88. 9% nasal epithelium from patients with chronic rhinosinusitis expressed SleX while 14.3% in normal control. Expression of SleX in nasal epitheliums from patients with chronic rhinosinusitis were higher than that in normal control. There were significant difference between two groups. Conclusion： Nasal epithelium from patients with CRS is highly expressed SleX. It may involve the occurence of chronic rhinosinusitis.

关 键 词：鼻窦炎 唾液酸Lewis-X 鼻黏膜 上皮细胞 E选择素 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]