雌激素对胰岛β细胞的作用及其机制  

Effect of Estrogen on Pancreatic β-Cells

作　　者：梁鸿寅[1] 王喆[2] 甘立霞[2] 

机构地区：[1]第三军医大学学员旅五队,重庆市400038 [2]第三军医大学生物化学与分子生物学教研室,重庆市400038

出　　处：《医学分子生物学杂志》2008年第6期535-538,共4页Journal of Medical Molecular Biology

基　　金：国家自然科学基金( No.30670998);全军医学科研"十一五"计划国际合作项目(No.06H025)~~

摘　　要：女性绝经后,2型糖尿病的发病率显著增加,雌激素替代治疗(hormone replacement therapy,HRT)能有效改善症状。以往通常认为雌激素是通过增强胰岛素的敏感性,改善糖、脂代谢的紊乱,从而缓解胰岛素抵抗。最近的研究表明,除上述机制外,雌激素直接作用于胰岛β细胞,防止其凋亡和促进胰岛素的分泌在其中也起着关键的作用。The incidence of T2DM is remarkably increased in postmenopausal women. Hormone replacement therapy （HRT） with estrogen has been clinically used to improve the T2DM climacteric symptoms. Previously, the effectiveness of estrogen HRT was thought to be mainly correlated with the enhancement of insulin sensitivity and improvement in glucose and lipid metabolism. Recently, accumulative evidence has shown that estrogen directly affects the multiple functions of pancreatic beta ceils such as preventing apoptosis and promoting insulin secretion of the cells, which provides new mechanism for HRT-based therapy.

关 键 词：雌激素 胰岛Β细胞 胰岛素抵抗 受体 

分 类 号：R335.6[医药卫生—人体生理学]