复方转移因子激发CD4^+T淋巴细胞的实验研究  

Study on traditional medicine compound transfer factor provocate CD4^+T lymphocyte of experiment

作　　者：李玉虎[1] 缪株雷[1] 程国强[1] 张辉[1] 侯庆萍[1] 

机构地区：[1]上海中医药大学,201203

出　　处：《中国实用医药》2008年第31期5-7,共3页China Practical Medicine

摘　　要：目的用化疗药物建立免疫细胞抑制的动物模型,以免疫细胞为观察指标评价复方转移因子的提高免疫细胞的能力。方法用环磷酰胺(CTX)灌胃(100 mg/kg),隔天一次,连续五次,造成免疫功能抑制的动物模型,通过不同实验组用药前后免疫细胞的变化,以评价复方转移因子高、中、低(相当人用量的2、5、10倍)剂量组是否能提高实验动物的免疫细胞。结果复方转移因子能显著提高实验小鼠白细胞数量,复方转移因子低、中、高剂量组与模型组比较,P<0.01,差别有极显著性;复方转移因子能显著提高实验小鼠淋巴细胞百分比及CD4+T淋巴细胞的绝对数,P<0.01,差别有极显著性。结论复方转移因子能提高实验小鼠WBC及CD4+T淋巴细胞的数量,并与剂量有关。Objective Animal model of immunosuppression has been found by chemotherapeutics. Ability of traditional Chinese medicine compound transfer factor improve immunoeyte, this result may be evaluated by immunocyte as a index. Methods Animal model of immunosuppression has been found by using eyclop- hosvnamide for intragastric administration, one time each other day, lavaging 5 times consecutively. Evaluated traditional Chinese medicine compound transfer factor high,medium,low dosage groups（ equal to 2,5,10times of people using） improve or not immunoeyte of experimental animals through changes of immunoeyte before and af- ter different experimental groups have been given to medicines. Result Traditional Chinese medicine compound transfer factor can increase remarkably amounts of WBC. Traditional Chinese medicine eompound transfer factor high,medium,low dosage groups compare to model group ,P 〈 0.01 ,the difference is extraordinary significance. It can elevate remarkably percentages of lymphocyte and absolute numbers of CD4^＋ T lymphocyte of experimental mouses, P 〈 0. 01, the difference is extraordinary significance. Conclusion Traditional Chinese medicine compound transfer factor can boost quantums of WBC and CD4^＋ T lymphocyte of experimental mouses, concerned with its dosages.

关 键 词：复方转移因子 CD4^+T淋巴细胞 环磷酰胺 动物模型 

分 类 号：R392[医药卫生—免疫学]