加味小柴胡汤联合干扰素治疗HbeAg阳性慢性乙型肝炎疗效初步临床观察  

The clinical observation of Jiaweixiaochaihu combined with interferon treatment of chronic hepatitis B HbeAg positive preliminary

作　　者：张迎春[1] 刘中景[1] 

机构地区：[1]青岛市传染病医院,266033

出　　处：《中国实用医药》2008年第33期50-51,共2页China Practical Medicine

摘　　要：目的观察中药复方加味小柴胡汤联合干扰素对HbeAg阳性慢性乙型肝炎的治疗效果。方法85例HBeAg阳性慢性乙型肝炎患者随机分为治疗组40例、对照组45例。对照组用重组干扰素a-2b,治疗组在对照组用药基础上加用中药复方。比较两组患者抗病毒、保肝及用药不良反应方面的差异。结果治疗组能明显减轻干扰素不良反应(P<0.05);肝功能恢复与对照组比较差异有统计学意义(P<0.05);HBeAg、HBV DNA阴转率及HbeAb阳转率分别为53%、56%、42%,与对照组比较差异有统计学意义(P<0.05)。结论加味小柴胡汤联合干扰素治疗HbeAg阳性慢性乙型肝炎较单纯应用干扰素可明显提高病毒学应答率、生化学应答率,并能减少用药不良反应,具有较好的治疗作用。Objective To observe the effects of Chinese native medicine combined with IFNa-2b to eantigen positive chronic heaptitis B （CHB） Methods Eigthy five patients with e-antigen positive CHB were selected and divided randomly into two groups：the therapeutic group was treated by Chinese native medicine combined with IFNa-2b, The control group was treated by IFNa-2b, All of patients were treated for 6 months, Index of virus and liver function were compared. Results The therapeutic group can significantly reduce the adverse effects of interferen（P 〈0. 05）. The ratio of negative transformation of HBeAg,HBVDNA and e-antibedy were separately 53%, 56% and 42% ,compared with the control group there were significant differente （ P 〈0. 05 ）. Conclusion The therapeutic group was better than the control group on the recover of liver function and the promotion of virus content during the treatment, and can significantly reduce the adverse drug reactions, with a better therapeutic effect.

关 键 词：加味小柴胡汤 A-2B干扰素 HBEAG阳性 慢性乙型肝炎 

分 类 号：R512.62[医药卫生—内科学] R277.794[医药卫生—临床医学]