舒必利片稳定性的考察  

Inspecting the stability of sulpiride tablets

作　　者：赵新静[1] 高剑锋[2] 路伟[2] 柳玉勇[1] 任敏[1] 

机构地区：[1]山东省安康医院,272051 [2]济宁市药品检验所

出　　处：《中国现代药物应用》2008年第24期48-50,共3页Chinese Journal of Modern Drug Application

摘　　要：目的考察舒必利片的稳定性。方法采用紫外分光光度法测定含量,高效液相色谱法测定有关物质;其性状、外观、脆碎度、溶出度的考察均采用中国药典规定的方法。结果试制的3批样品经高温、高湿、强光、加速试验及室温留样观察2年,各项指标均无明显变化。结论本品应密封包装,注意防止吸潮。在2年内质量稳定。预测有效期为2年。Objective To inspect the stability of sulpiride tablets. Methods Its contents were determined with Uhraviodet spectrophotometry, And degradation products with HPLC , its the properties, hardness, dissolution were inspected with the method of Chinese Pharmacopoeia. Results By means of experiment on three kinds of samples produced in the experiments and obtained in room temperature,the tablets had no change in 24 months. Conclusions If the tablets is sealed and kept from wet, they are steady in 24 months. And the predicated effective deadline is tow years.

关 键 词：舒必利片 稳定性 紫外分光光度法 高效液相色谱法 

分 类 号：R927.11[医药卫生—药学]