科素亚对原发性高血压患者颈动脉IMT及左室肥厚的影响  

作　　者：田骆冰[1] 夏岳[1] 戚国庆[1] 

机构地区：[1]河北医科大学第一医院心内科

出　　处：《当代医学》2008年第12期19-21,共3页Contemporary Medicine

摘　　要：目的探讨科素亚对原发性高血压患者颈动脉内膜中层厚度（IMT）及左室肥厚（LVH）的影响。方法选取原发性高血压患者80例随机分成治疗组（科素亚50mg，40例）和对照组（硝苯地平10～20mg，40例）。总疗程共6个月．治疗前后用彩色超声多普勒检测颈动脉IMT和左室相关数据，计算左室重量指数（LVMI）。结果两组血压与治疗前比较均显著降低（P〈0.01），两组降压效果无显著差异（P〉0.05）。治疗组治疗后颈动脉IMT及LVMI与治疗前比较均能显著降低（P〈0．05）．对照组治疗前后IMT及LVMI差异无显著意义（P〉0．05）。结论科素亚有良好的降压效果和对颈动脉、心脏结构重构均有逆转作用。Objective To observe the efficacy of losartan reversing carotid （IMT） and （LVH） in patients with essential hypeitension .Methods 80 with essential hypertension were divided into two groups, one was treated with losartan（treatment group,n=40） and another was treated with Nifedipine （conteol group ,n=40）.before and after six months treatment,the changes of left IMT and the left ventricular mass index（LVMI） were observed. Results before and after treatment in these two groups, the level of blood pressure decreasing were almost the same （P〉0.05）;carotid IMT and LVMI decreased significantly in treatment group （P〈0.05）, but in control group ,these changes were not significantly （P〉0.05）.Conclusion losartan can signifcantly reverse carrotid IMT and LVH in patients with EH.

关 键 词：高血压 颈动脉内膜中层厚度 左室重量指数 科素亚 

分 类 号：R544.1[医药卫生—心血管疾病]