HLA-DRB1基因与湘西土家、汉族人群不明原因反复流产的相关性研究  

Study on the correlation between HLA-DRB1 genes and unexplained recurrent spontaneous abortions in Xiangxi Tujia and Han population

作　　者：程秋蓉 罗雪梅[2] 周昌菊[2] 杜建林[3] 

机构地区：[1]湘西自治州人民医院妇产科,湖南省吉首市416000 [2]吉首大学医学院 [3]中南大学湘雅三医院妇产科

出　　处：《中国综合临床》2008年第12期1226-1228,共3页Clinical Medicine of China

基　　金：湖南省教育厅资助科研项目（05C131）;湖南省湘西自治州科技计划项目（2005CXZ13）

摘　　要：目的探讨HLA-DRBI基因多态性与湘西土家族、汉族人群不明原因反复流产（URSA）的遗传关联性。方法采用聚合酶链反应一序列特异性引物（PCR—SSP）技术，对76例湘西土家族、68例汉族人群URSA患者和82例湘西土家族、75例汉族人群健康对照者的HLA-DRB1等位基因进行分析。结果①土家族、汉族URSA组的DRB1＊ 04基因频率显著高于土家族及汉族对照组（RR〉1，Pc〈0．01）；DRB1＊ 12的基因频率显著低于对照组（RR〈1，P，〈0．01）。②土家族URSA组的DRBl＊07基因频率明显高于汉族URSA组（18．08％比5．28％，Pc〈0．01）。结论HLA-DRBI＊ 04可能是湘西土家族、汉族人群不明原因反复流产的易感基因．HLA-DRB1 ＊12可能为保护基因。Objective To analyze the HLA- DRB1 gene polymorphism and the hereditary association with unexplained recurrent spontaneous abortions （ URSA ） in a population of Tujia and Han nationality from west part of Hunan province in China. Methods The alleles at the HLA-DRB1 typing were analyzed by polymerase chain reaction-sequence specific primers （ PCR-SSP ） in 76 URSA Tujia population and 68 URSA Han population and 82 healthy Tujia population and 75 healthy Han population. Results ①DRB1 ＊ 04 frequency of URSA in Tujia and Han population was strikingly higher than that of the healthy Tujia and Han population （ RR 〉 1, Pc 〈 0.01 ）, but the DRBI ＊ 12 frequency was strikingly lower than that of the healthy Tujia and Han population respectively（ RR 〈 1 ,Pc 〈0.01 ）. ②DRB1 ＊ 07 frequency of URSA in Tujia population was strikingly higher than that of the URSA in Han population 118.08% ：5.28%, Pc 〈 0. 01 ）. Conclusion HLA-DRB1 ＊ 04 maybe predisposing genes of URSA in Tujia and Han population,and HLA-DRB1 ＊ 12 maybe associated with an antagonist effect in the pathogenesis of URSA in this population.

关 键 词：流产 HIA-DR基因 土家族 

分 类 号：R714.21[医药卫生—妇产科学]