基于杯[4]芳烃的手性识别  

Chiral Recognition Based on Calix[4]arene

作　　者：卿光焱[1] 刘顺英[2] 何永炳[1] 

机构地区：[1]武汉大学化学与分子科学学院,武汉430072 [2]华东师范大学新药创制先进技术研究院,上海200062

出　　处：《化学进展》2008年第12期1933-1944,共12页Progress in Chemistry

基　　金：国家自然科学基金项目(No.20372054,20572080)资助

摘　　要：手性杯芳烃是一类重要的主体化合物,在手性识别、对映体分离和不对称催化等方面有着广泛的用途。杯[4]芳烃因其稳定的构象和易于修饰的特点,成为研究最为广泛的杯芳烃分子,其中大量的文献报道了能够用于对映体识别和检测的手性杯[4]芳烃。在手性识别的研究中,荧光、紫外和核磁是3种最常见的研究方法,本文根据这3种方法进行分类,综述了近年来以杯[4]芳烃为分子骨架的手性受体的合成及其在手性识别中的应用。最后对手性杯[4]芳烃的发展前景作了展望。Chiral calixarenes are a class of important host compounds and have wide applications in chiral recognition, enantiomer separation and asymmetrical catalysis. Calix[4] arene is investigated most widely due to its stable conformation and easy derivatization. Among them lots of works reported the chiral calix [ 4 ]arenes can be used in enantiomeric recognition and dectection. Fluorescence, UV-vis and NMR are the most common methods in the research of chiral recognition. According to these methods, the latest research progress in the synthesis of chiral receptors based on calix[4]arenes and their applications in the chiral recognition are summarized. The prospect of chiral calix[4] arene is also discussed.

关 键 词：手性识别 杯[4]芳烃 对映体检测 

分 类 号：O621.1[理学—有机化学] O641.3[理学—化学]