肝素在生长因子控制释放中的应用  

Heparin for Growth Factor Delivery Systems

作　　者：丁珊珊[1] 崔元璐[1] 宫政[2] 尹玉姬[2] 姚康德[2] 

机构地区：[1]天津中医药大学中医药研究院现代中药发现与制剂技术教育部工程研究中心,天津300193 [2]天津大学材料科学与工程学院,天津300072

出　　处：《化学进展》2008年第12期1998-2011,共14页Progress in Chemistry

基　　金：国家自然科学基金项目(No.30670572);天津市应用基础研究重点项目(No.06YFJZJC01900)资助

摘　　要：典型的抗凝血药物肝素作为硫酸化的多糖在体内具有多重生物活性,而这些生物活性是通过与生长因子和细胞因子等蛋白质的相互作用来发挥的。由于它与肝素亲和性生长因子具有特异的糖胺聚糖-蛋白质相互作用,近年来被广泛地应用于生长因子的控制释放中,以达到稳定负载于载体材料中的生长因子并保持其生物活性、延缓释放的作用。本文介绍了近年来肝素在组织工程用水凝胶型生长因子控制释放系统中应用研究的最新进展。Heparin, a sulfated polysaccharide and a representative antithrombotic drug, has special binding affinity with a number of biologically important proteins such as growth factors and cytokines, and thereby plays an essential role in the regulation of various biological signaling. Heparin-containing matrices or delivery systems immobilize and protect high-affinity heparin-binding growth factors from degradation, release growth factor in a sustained manner, and increase both the stability and activity of the growth factor. In this review, we summarize the recently developed hydrogel matrices and scaffolds which contain heparin for growth factor delivery in tissue engineering.

关 键 词：肝素 生长因子 水凝胶 释放 生物活性 

分 类 号：O636[理学—高分子化学] R318.08[理学—化学]