5-氯-4-羟基-2-(1H)吡啶酮的合成  

Study on the synthesis of 5-chloro-4-hydroxy-2-(1H)-pyridinone

作　　者：田志高[1] 刘芳[2] 刘安昌[2] 谭珍友[2] 张良[2] 

机构地区：[1]襄樊学院化学与生物科学系,湖北襄樊441053 [2]武汉工程大学湖北省新型反应器与绿色化学工艺重点实验室,湖北武汉430074

出　　处：《化学试剂》2008年第12期939-940,共2页Chemical Reagents

摘　　要：以丙二腈、原乙酸三甲酯等为原料合成标题化合物,经缩合、环和、氯代、水解反应而得,通过改进其生产工艺,总产率可达到65.6%。跟其他合成方法比较起来,此方法步骤短、反应时间短、总收率高,更容易工业化生产。5-Chloro-4-hydroxy-2-（ 1H）-pyridinone was prepared from the raw materials malononitrile and 1, 1, 1-trimethoxyethane in four steps including： combination, eyelization, chlorination, and hydrolysis that could result in a final yield of 65.6%. Compared to other synthetic methods, this one had the advantage of a shorter preparation procedure, a shorter reaction time and a higher product yield and could be more readily realized in commercial scale.

关 键 词：5-氯-4-羟基-2-(1H)吡啶酮 丙二腈 原乙酸三甲酯 合成 

分 类 号：O626.3[理学—有机化学]