PPEGMEA-g-PMAA全亲水接枝共聚物包埋甲氨喋呤体外控释的研究  

Studies on Controlled Drug Release in vitro of Methotrexate Loaded by PPEGMEA-g-PMAA Double Hydrophilic Graft Copolymer

作　　者：黄晓炜[1] 顾丽娜[2] 陆国林[2] 黄啸[1] 张亚琴[2] 黄晓宇[2] 

机构地区：[1]复旦大学附属肿瘤医院妇科复旦大学上海医学院肿瘤学系,上海200032 [2]中国科学院上海有机化学研究所,上海200032

出　　处：《化学学报》2008年第23期2653-2657,共5页Acta Chimica Sinica

基　　金：上海市纳米专项(No.0652nm031);上海市青年科技启明星计划(No.07QA14066);中国科学院青年人才领域前沿项目;卫生部笹川医学奖学金同学会科研启动基金资助项目.

摘　　要：以全亲水接枝共聚物PPEGMEA-g-PMAA为载体材料,以甲氨喋呤(MTX)为模型药物,通过物理包埋和化学键合法制备MTX药物缓释体系,探讨了pH值、制备方法等对载药量(DLC)、包埋率(DLE)和释药行为等的影响,两种体系均可以通过改变pH值来控制药物的释放和释放速率.Methotrexate-loaded polymeric micelles using PPEGMEA-g-PMAA double hydrophilic graft copolymer as carrier were prepared by physical entrapping and chemical bonding. The effects of pH and preparation method on drug loading content （DLC）, drug loading efficiency （DLE） and drug release were studied. Drug release of both micelles can be controlled by pH.

关 键 词：全亲水接枝共聚物 药物控释 甲氨喋呤 

分 类 号：R94[医药卫生—药剂学]