山西省70家医院抗菌药物消耗与细菌耐药性的相关性分析  

Correlation between the Consumption of Antibacterial Drugs and the Bacterial Resistant in 70 Hospitals in Shanxi Province

作　　者：王治海[1] 李梅 范惠霞[3] 严虹霞[1] 

机构地区：[1]山西省肿瘤医院,太原市030013 [2]山西省医疗机构管理研究所,太原市030013 [3]山西省儿童医院,太原市030013

出　　处：《中国药房》2008年第35期2744-2747,共4页China Pharmacy

基　　金：山西省软科学研究项目(2007041030-03)

摘　　要：目的:探讨细菌耐药性与抗菌药物消耗的相应关系。方法:对山西省70家医院连续3年抗菌药物的用药频度作统计和排序;对同期部分致病菌进行年度耐药率统计,并进行相关结果比较。结果:销售排序前20位的抗菌药物品种变化不明显。用药频度值高且排序列前的品种,正是细菌容易产生高度耐药的品种。细菌对某药耐药率超过50%以上时,耐药率至少4年内不会随其销量变化明显下降。第4代头孢菌素头孢吡肟在销售增长的同时,细菌耐药率增长严重放大;万古霉素销售增长,但耐药率下降;抗菌药物复方制剂在销售明显增长的情况下,仍保持较好的抗菌活性。结论:抗菌药物的大量使用与细菌耐药性变化有直接关系,应加强临床抗菌药物管理,提高合理用药水平。OBJECTIVE ： To investigate the relationship between the variation of bacterial - resistant and the consumption of antibacterial drugs. METHODS： The DDDs and its sequence of antibacterial drugs in 70 hospitals in Shanxi province over 3 years and the synchronic annual resistant rates of some pathogenic bacteria were analyzed statistically and the correlation between the variation of bacterial- resistant and the drug consumption was analyzed. RESULTS： In terms of variety, there was no obvious change for the top twenty antibacterial drugs. The antibacterial drugs with high DDDs thus ranked the lead were those kinds that with high bacterial drug resistance. At a value of over 50%, the bacterial drug resistance rate would not decrease obviously with the variation of the drug consumption. The drug resistance rate increased greatly with the increase of the consumption of the forth generation of cephalosporins cefepime. The consumption of vancomycin increased, but its resistance rate decreased. The antibacterial compound preparation showed satisfactory antibacterial activity even if its consumption had a marked increase. CONCLUSION ： There is a direct relation between the consumption of antibacterials in large quantity and the variation of drug resistance. It is necessary to strengthen clinical management on antibacterials to raise rational drug use level.

关 键 词：细菌耐药性 抗菌药物 用药频度 

分 类 号：R95[医药卫生—药学] R969.3