我院2005～2007年抗菌药物使用与常见感染病原菌耐药情况分析  

Analysis of the Use of Antibacterials and Drug Resistance of Common Pathogenic Bacteria Causing Hospital Nosocomial Inflection During the Period 2005～2007

作　　者：胡宝荣[1] 牟阳[1] 师清芝[1] 

机构地区：[1]哈尔滨医科大学附属第一医院,哈尔滨市150001

出　　处：《中国药房》2008年第35期2747-2750,共4页China Pharmacy

摘　　要：目的:了解我院2005～2007年抗菌药物的使用情况及病原菌的分布与耐药性。方法:根据我院2005～2007年检出细菌耐药情况与药品管理记录进行统计分析。结果:大肠埃希菌产超广谱β-内酰胺酶率呈逐年上升趋势;耐甲氧西林金黄色葡萄球菌占金黄色葡萄球菌总数的比例为79.4%、66.3%、73.9%;抗菌药物的使用频率逐年上升,使用最多的2类抗菌药物为第3代头孢菌素和氟喹诺酮类。结论:临床医师应合理选用抗菌药物,减少细菌耐药。OBJECTIVE： To investigate the use of antibacterials and to evaluate the distribution and drugs resistance of pathogenic bacteria causing hospital nosocomial infection between 2005 and 2007 in our hospital. METHODS： The antibiotic resistance and the data of drug use from 2005 to 2007 in our hospital were analyzed statistically. RESULTS： Over the 3 years, the production rate of ESBLs of Escherichia.coli ascended year by year. The proportion of methicillin resistant staphylococcus aureus （MRSA） in staphylococcus aureus were 79.4%, 66.3% and 73.9% respectively over the 3 years. The DDDs of antimicrobials showed an year- on- year increase, with third -generation eephalosporins and fluoroquinolones topping the first two places. CONCLUSION： Antibacterial drugs should be used rationally in clinical practice so as to reduce antibiotic resistance.

关 键 词：抗菌药物 病原菌 耐药性 

分 类 号：R95[医药卫生—药学] R969.3