25例横纹肌溶解症的临床特点分析  

Clinical analysis of twenty-five patients with rhabdomyolysis

作　　者：张磊[1] 谢院生[1] 陈香美[1] 

机构地区：[1]解放军总医院肾病科解放军肾脏病研究所,北京100853

出　　处：《军医进修学院学报》2008年第6期463-465,共3页Academic Journal of Pla Postgraduate Medical School

基　　金：国家自然科学基金资助项目(30570856);北京市自然科学基金资助项目(7063093)

摘　　要：目的:了解横纹肌溶解症的临床发病特点以及预后。方法:总结分析25例横纹肌溶解症的临床资料及治疗预后情况。结果:发病人群以青年男性为主,尤其是运动性横纹肌溶解症的患者;运动、热射病、挤压、药物、自身免疫性疾病等均可导致横纹肌溶解,本组病例运动性横纹肌溶解症占48.0%;起病急,病程短;均有血肌酸激酶增高,平均值为38 642U.L-1;多数病例伴急性肾衰竭(72.0%);88.0%的患者好转或痊愈,肾功能恢复正常或发病前水平,12.0%的患者死亡,死亡病例肌酸激酶显著高于好转病例。结论:横纹肌溶解症是一种可由运动等多种原因所致的急性疾病,均有肌酸激酶增高,常合并急性肾衰竭。及时诊治大多数可好转或痊愈,少数病情严重者预后差。Objective： To investigate the clinical feature and the prognosis of rhabdomyolysis.Methods： To analyze sexuality,age,the cause of RM and renal function,the peak of CK,the changes of clinical status and the prognosis of the 25 patients.Results： The incidence of crowd of rhabdomyolysis were male young,especially the exercise-induced rhabdomyolysis.Many causes could induce rhabdomyolysis,such as exercise,thermoplegia,crash injury,drugs or autoallergic disease.In this group,exercise-induced rhabdomyolysis was 48.0%.Rhabdomyolysis has a flash onset and short course of disease.The CK value increased in all of patients,the general average of CK was 38 642U·L^-1.Most of the patients were with acute renal failure（72.0%）.Improve rate was 88.0%,12 patients was dead.The CK of death group was significant higher than that of improved group.Conclusion： Rhabdomyolysis was an acute disease caused by more etiology such as exercise,with the high CK value and acute renal failure.Most patients of RM will improve,few serious patients will die.

关 键 词：横纹肌溶解 肾功能衰竭 肌酸激酶 

分 类 号：R685.5[医药卫生—骨科学]