冠心病痰瘀辨证与相关炎症标志物关系初探  

Study on relationship between phlegm stasis syndrom differentiation and corresponding inflammatory markers of coronary heart disease

作　　者：刘艳[1] 叶武[1] 王坤根[1] 毛威[1] 华军益[1] 蔡宏文[1] 陈杰[2] 陈隽妍[2] 许志良[1] 

机构地区：[1]浙江中医药大学附属第一临床医学院浙江省中医院,杭州310006 [2]浙江中医药大学,杭州310053

出　　处：《中华中医药杂志》2008年第12期1121-1124,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：浙江省科技攻关计划项目(No.2007C33022)

摘　　要：目的:探讨冠心病(胸痹)痰瘀辨证与炎症标志物超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、可溶性CD40配体(soluble CD40 ligand,sCD40L)表达的关系。方法:入选60例冠心病患者,分为非痰非瘀组(n=20),痰凝心脉组(n=20),痰瘀互结组(n=20),另选健康志愿者作为正常对照(n=20),免疫透射比浊法测hs-CRP,酶联免疫吸附(ELISA)法测血清sCD40L水平。结果:与正常对照组比,非痰非瘀组、痰凝心脉组和痰瘀互结组患者血清hs-CRP和sCD40L水平均升高(P<0.05或P<0.01);与非痰非瘀组比较,痰凝心脉组及痰瘀互结组患者血清hs-CRP水平逐渐升高(P<0.05或P<0.01),且二者之间的差异具有统计学意义(P<0.01),而血清sCD40L水平略高于非痰非瘀组(P>0.05),且两组间的差异没有统计学意义(P>0.05)。相关性分析可见,血清hs-CRP水平与冠心病痰瘀辨证之间有相关性(P<0.05或P<0.01)。结论:血清炎症标志物hs-CRP水平可为冠心病痰瘀辨证分型提供客观依据。Objective： To explore the relationship between syndrome differentiation of phlegm and blood stasis of coronary heart disease and the levels of high-sensitivity C-reactive protein （hs-CRP） and soluble CD40 ligand （sCD40L）. Methods： Sixty patients with coronary heart disease were evenly divided into three groups randomly： the non-phlegm and non- stasis group（n=20）, the congealing phlegm of heart vessels group（n=20）and the intermingled phlegm and blood stasis group（n=20）. Twenty healthy volunteers was as the control group（n=20）. The level of hs-CRP was detected with immunity transmission turbidity. The levels of sCD40L was determined by ELISA. Observe the differences within groups. Results： The levels of serum hs-CRP and sCD40L showed higher in the non-phlegm and non-stasis group, the congealing phlegm of heart vessels group and the intermingled phlegm and blood stasis group than those of the control group （P〈0.05 or P〈0.01）. Compared with the non-phlegm and non-stasis group, patients in the congealing phlegm of heart vessels group and the intermingled phlegm and blood stasis group have higher levels of hs-CRP （P〈0.05 or P〈0.01）, and there was statistics significance between the two groups （P〈0.01）. It showed the level of serum hs-CRP was related with syndrom differentiation of phlegm and blood stasis in coronary heart disease patients. Conclusions： Syndrom differentiation of phlegm and blood stasis in coronary heart disease may be according to the level of serum hs-CRP.

关 键 词：冠心病 痰瘀辨证 超敏C反应蛋白 可溶性CD40配体 

分 类 号：R259[医药卫生—中西医结合]