不同地区及途径HIV／HCV合并感染状况调查  

Investigation of HIV co-infection with hepatitis C virus through different infectious routes

作　　者：张旻[1] 胡清海[1] 赵飞[2] 孙峰 段松[4] 孟向东[5] 卢春明[6] 刘静[1] 丁海波[1] 范霞[1] 尚红[1] 

机构地区：[1]中国医科大学附属第一医院卫生部艾滋病免疫学重点实验室,沈阳110001 [2]河南省疾病预防控制中心 [3]新疆维吾尔自治区伊犁哈萨克自治州疾病预防控制中心 [4]云南省德宏州疾病预防控制中心 [5]吉林省疾病预防控制中心 [6]辽宁省疾病预防控制中心

出　　处：《中国公共卫生》2008年第12期1409-1411,共3页Chinese Journal of Public Health

基　　金：“十五”国家科技攻关课题资助项目(2004BA71912);卫生部艾滋病防治研究项目(WA2006-02);辽宁省教育厅科技攻关计划(2012215112);辽宁省教育厅重点实验室项目(20060906);2004年省教育厅项目(2004F122)

摘　　要：目的了解中国不同地区、不同感染途径人类免疫缺陷病毒(HIV)合并丙型肝炎病毒(HCV)感染情况。方法调查既往有偿采供血173人、静脉吸毒89人和性途径194人的HIV感染者人口学、感染途径、献血/卖血史、吸毒史、同性性行为史、婚外性行为史及检测HCV-IgG抗体。结果总HCV-IgG抗体阳性率63.24%;既往有偿采供血、静脉吸毒和性途径HIV感染者HCV-IgG阳性率分别为95.40%,98.88%,18.04%;合并HCV感染的危险因素为既往有偿采供血(OR=89.84,95%CI=40.31～200.24)和静脉吸毒感染(OR=363.72,95%CI=48.90～∞);河南省和新疆维吾尔自治区性途径合并HCV感染率分别为19.81%,25%,明显高于辽宁省的2.94%(P<0.01)。结论HIV感染者总HCV-IgG阳性率显著高于我国一般人群。经性接触感染HIV者的HCV感染率显著低于经静脉吸毒和经血途径,经吸毒感染HIV和经既往有偿采供血感染HIV是感染HIV的危险因素。经性感染HIV由于地域和性伴不同,HCV合并感染率差异有统计学意义。Objective To investigate HIV co-infection with hepatitis C virus through different infectious routes in different regions in China. Methods 174 HIV-1-infected former plasma donors（FPD）, 89 HIV-1-infected injected drug users （IDU） and 194 HIV-1-infeeted heterosexuals were enrolled. Demology, infectious route, data of plasma donor, injected drug, homosexual, heterosexual were investigated and HCV IgG were measured. Results The total posotive rate of HCV-IgG was 63.24%, and 95.40% in FPD, 98.88% in IDU, 18.04% in heterosexual, respectively. The risk factor of HIV co- infected with HCV were FPD（ OR = 89.84, 95 % CI = 40.31 - 200.24） and IDU（ OR = 363.72, 95 % CI = 48.90 - ∞ ）. The infected rate of co-infection in Henan and Xinjiang province were 19.81%, 25.00 %, it was more higher than 2.94 % in Liaoning province. Conclusion The total posotive rate of HCV-IgG in HIV infection indivduals was higher than common population. The rate of HCV infected in heterosexual was lower than that of FPD and IDU. FPD and IDU were risk factor of HIV co-infection with HCV. The different region and sex parther resulted in difference of HCV co-infection.

关 键 词：人类免疫缺陷病毒(HIV) 丙型肝炎病毒(HCV) 合并感染 

分 类 号：R512.91[医药卫生—内科学]