幽门螺杆菌毒力因子的研究进展  

Progress of the Helicobacter Pylori′s Virulence Factors

作　　者：唐炜[1] 张尤历[2] 

机构地区：[1]江苏大学临床医学院,江苏镇江212001 [2]江苏大学附属医院消化科,江苏镇江212001

出　　处：《医学综述》2008年第24期3688-3693,共6页Medical Recapitulate

基　　金：江苏省社会发展项目(BS2006041)

摘　　要：幽门螺杆菌(HP)是造成上消化道疾病的主要因素。HP能分泌许多致病因子,这些致病因子分为定植因子和毒力因子。HP的各种毒力因子均具有遗传多样性和地区分布的差异,与不同HP相关性疾病之间存在相关性。毒力因子在病变过程中起的作用不尽相同,决定感染后炎症、溃疡及胃癌等临床转归。本文就其研究现状予以综述。Helicobacter pylori（HP） is the major factor causing disease of upper digestive tract HP can create a lot of pathopoiesia factors,including planting factors and virulence factors. The virulcnee factors have the hereditary diversity. The virulence factors have different effects in the process of lesions. They can influence the clinically revolution such as inflammation, ulcer and gastric carcinoma. This article reviewed the current progress of virulence factors.

关 键 词：幽门螺杆菌 毒力因子 遗传多样性 疾病转归 

分 类 号：R378.2[医药卫生—病原生物学]