应用化合物组释放动力学方法评价银翘解毒片的释放特征(英文)  

Application of Chemomic Release Kinetics to Evaluation of the Release Characteristics of Yinqiaojiedu Tablets

作　　者：陈立兵[1,2] 王中华[1,3] 傅丹丹[1,2] 凌昳[1,2] 葛卫红[2] 顾景凯[3] YORK Peter 邵群 张继稳[1] 

机构地区：[1]中国科学院上海药物研究所药物释放系统研究中心 [2]浙江中医药大学药学院 [3]吉林大学药物代谢研究中心 [4]Institute of Pharmaceutical Innovation,University of Bradford

出　　处：《中国天然药物》2008年第6期450-455,共6页

基　　金：supported by Hi-Tech Research and Development Program of China(No. 2006AA02Z336);National Key Technology R&D Program of China(No. 2006BAI098B08-08);New Drug Basic Research Program of the Shanghai Institute of Materia Medica,Chinese Academy of Sciences (No.O7G603F015)~~

摘　　要：目的:考察中药化合物组释放动力学新理论在银翘解毒片释放特征评价中的适用性。方法:以Kalman滤波法为基础,进行紫外分光光度法测定银翘解毒片化合物组标准谱、线性、精密度、稳定性等方法学研究,测定银翘解毒片及其粉末的化合物组释放特征。结果:方法学结果表明,在0.112～1.120mg生药/mL范围内银翘解毒片化合物组呈线性相关(r=0.9997);高、中、低化合物组浓度测定的RSD分别为0.05%、0.07%和0.31%,浓度分别为0.278,0.556,和1.120mg生药/mL的供试液化合物组在24h内稳定。结论:化合物组释放度能简洁、可视、直观地反映银翘解毒片多组分释放动力学特征,中药化合物组释放动力学新理论可以定量地揭示传统中药制剂的新内涵或其给药系统的活性组分释放特征。AIM： To verify the applicability of a new theory for chemomic release kinetics of traditional Chinese medicines using the release characteristics of Yinqiaojiedu tablets. METHOD： The methodological studies of the preparation of chemomic standard spectrum, linearity, precision and stability tests of the chemomes of Yinqiaojiedu tablets were processed by UV spectrophotometry and Kalman filter methods. The chemomic release profiles of Yinqiaojiedu tablets and powders were determined. RESULT： The methodology studies indicated that there was a good linearity of chemomic concentration of Yinqiaojiedu tablets within the range 0.112 to 1.120 mg total herbs / mL （r = 0.999 7）. The values of RSD tested at three chemomic levels were 0.05 %, 0.07 % and 0.31% respectively. The chemomic solutions were stable for 24 h at concentrations of 0.278, 0.556, and 1.120 mg total herb / mL. CONCLUSION： The chemomic release profiles demonstrated multi-component release kinetics illustrated using a simple visualization approach. The new theory of chemomic release kinetics may advantageously provide a quantitative description for the release of the active agents from traditional Chinese medicines from a conventional dosage form or drug delivery system.

关 键 词：化合物组 化合物组释放动力学 Kalman滤波法 多组分 银翘解毒片 

分 类 号：R969.1[医药卫生—药理学]